Systemic hemodynamics during hyperbaric oxygen exposure in rats

L. E.B. Stuhr; G. W. Bergo; I. Tyssebotn

Systemic hemodynamics during hyperbaric oxygen exposure in rats

L. E.B. Stuhr
, G. W. Bergo
, I. Tyssebotn

Physiology and Biophysics

Department of Physiology

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The effect of 1-5 bar O₂ on left ventricular pressure (LVP), maximal velocity of LVP rise (+dP/dt) and fall (-dP/dt), systolic arterial pressure (APsys), pulse pressure (ΔAP), heart rate (HR), and respiratory frequency (RF) was studied in anesthetized and conscious rats. At 1 bar O₂, all blood pressure parameters increased significantly (9-56%) in both groups of rats, while RF fell (11-12%). HR fell only in conscious rats, while arrhythmias occurred in both groups. Compression to 5 bar O₂ induced a significant further increase in all blood pressure parameters. HR fell further in the conscious rats. Arrhythmias were observed in increasing number during compression and at 5 bar O₂. Elevation in estimated oxygen-consumption of the heart was found both during compression and at 5 bar O₂. We conclude that O₂ exposure markedly stimulates the myocardium by elevating the LVP, +dP/dt, and -dP/dt, thus elevating APsys and ΔAP. Arrhythmias developed in both groups, while bradycardia occurred only in conscious rats.

Original language	English
Pages (from-to)	531-538
Number of pages	8
Journal	Aviation Space and Environmental Medicine
Volume	65
Issue number	6
State	Published - 1994

Cite this

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title = "Systemic hemodynamics during hyperbaric oxygen exposure in rats",

abstract = "The effect of 1-5 bar O2 on left ventricular pressure (LVP), maximal velocity of LVP rise (+dP/dt) and fall (-dP/dt), systolic arterial pressure (APsys), pulse pressure (ΔAP), heart rate (HR), and respiratory frequency (RF) was studied in anesthetized and conscious rats. At 1 bar O2, all blood pressure parameters increased significantly (9-56\%) in both groups of rats, while RF fell (11-12\%). HR fell only in conscious rats, while arrhythmias occurred in both groups. Compression to 5 bar O2 induced a significant further increase in all blood pressure parameters. HR fell further in the conscious rats. Arrhythmias were observed in increasing number during compression and at 5 bar O2. Elevation in estimated oxygen-consumption of the heart was found both during compression and at 5 bar O2. We conclude that O2 exposure markedly stimulates the myocardium by elevating the LVP, +dP/dt, and -dP/dt, thus elevating APsys and ΔAP. Arrhythmias developed in both groups, while bradycardia occurred only in conscious rats.",

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AU - Stuhr, L. E.B.

AU - Bergo, G. W.

AU - Tyssebotn, I.

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Y1 - 1994

N2 - The effect of 1-5 bar O2 on left ventricular pressure (LVP), maximal velocity of LVP rise (+dP/dt) and fall (-dP/dt), systolic arterial pressure (APsys), pulse pressure (ΔAP), heart rate (HR), and respiratory frequency (RF) was studied in anesthetized and conscious rats. At 1 bar O2, all blood pressure parameters increased significantly (9-56%) in both groups of rats, while RF fell (11-12%). HR fell only in conscious rats, while arrhythmias occurred in both groups. Compression to 5 bar O2 induced a significant further increase in all blood pressure parameters. HR fell further in the conscious rats. Arrhythmias were observed in increasing number during compression and at 5 bar O2. Elevation in estimated oxygen-consumption of the heart was found both during compression and at 5 bar O2. We conclude that O2 exposure markedly stimulates the myocardium by elevating the LVP, +dP/dt, and -dP/dt, thus elevating APsys and ΔAP. Arrhythmias developed in both groups, while bradycardia occurred only in conscious rats.

AB - The effect of 1-5 bar O2 on left ventricular pressure (LVP), maximal velocity of LVP rise (+dP/dt) and fall (-dP/dt), systolic arterial pressure (APsys), pulse pressure (ΔAP), heart rate (HR), and respiratory frequency (RF) was studied in anesthetized and conscious rats. At 1 bar O2, all blood pressure parameters increased significantly (9-56%) in both groups of rats, while RF fell (11-12%). HR fell only in conscious rats, while arrhythmias occurred in both groups. Compression to 5 bar O2 induced a significant further increase in all blood pressure parameters. HR fell further in the conscious rats. Arrhythmias were observed in increasing number during compression and at 5 bar O2. Elevation in estimated oxygen-consumption of the heart was found both during compression and at 5 bar O2. We conclude that O2 exposure markedly stimulates the myocardium by elevating the LVP, +dP/dt, and -dP/dt, thus elevating APsys and ΔAP. Arrhythmias developed in both groups, while bradycardia occurred only in conscious rats.

UR - https://www.scopus.com/pages/publications/0028352286

M3 - Article

C2 - 8074627

AN - SCOPUS:0028352286

SN - 0095-6562

VL - 65

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EP - 538

JO - Aviation Space and Environmental Medicine

JF - Aviation Space and Environmental Medicine

IS - 6

ER -

Systemic hemodynamics during hyperbaric oxygen exposure in rats

Abstract

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