Synthesis of the 6,7-bis[2-methoxycarbonyl(1,1-dideutero)ethyl] derivative of protoporphyrin IX dimethyl ester

Young Key Shim; Ravindra K. Pandey; Kevin M. Smith

doi:10.1002/(SICI)1099-1409(200003)4:2<185::AID-JPP179>3.0.CO;2-I

Synthesis of the 6,7-bis[2-methoxycarbonyl(1,1-dideutero)ethyl] derivative of protoporphyrin IX dimethyl ester

Young Key Shim
, Ravindra K. Pandey
, Kevin M. Smith

Institute for Lasers Photonics and Biophotonics

University of California at Davis

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A new total synthesis of a protoporphyrin IX derivative in which the α-methylene protons of the 13,17-(2-methoxycarbonylethyl) substituents are regioselectively deuterated is described. The deuterated porphyrin was obtained using the oxidative cyclization of an a, c-biladiene dihydrobromide. Copyright (C) 2000 John Wiley and Sons, Ltd.

Original language	English
Pages (from-to)	185-191
Number of pages	7
Journal	Journal of Porphyrins and Phthalocyanines
Volume	4
Issue number	2
DOIs	https://doi.org/10.1002/(SICI)1099-1409(200003)4:2<185::AID-JPP179>3.0.CO;2-I
State	Published - Mar 2000

Keywords

a, c-biladienes
Deuterium labeling
Heme proteins
Porphyrin synthesis

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10.1002/(SICI)1099-1409(200003)4:2<185::AID-JPP179>3.0.CO;2-I

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title = "Synthesis of the 6,7-bis[2-methoxycarbonyl(1,1-dideutero)ethyl] derivative of protoporphyrin IX dimethyl ester",

abstract = "A new total synthesis of a protoporphyrin IX derivative in which the α-methylene protons of the 13,17-(2-methoxycarbonylethyl) substituents are regioselectively deuterated is described. The deuterated porphyrin was obtained using the oxidative cyclization of an a, c-biladiene dihydrobromide. Copyright (C) 2000 John Wiley and Sons, Ltd.",

keywords = "a, c-biladienes, Deuterium labeling, Heme proteins, Porphyrin synthesis",

author = "Shim, \{Young Key\} and Pandey, \{Ravindra K.\} and Smith, \{Kevin M.\}",

year = "2000",

month = mar,

doi = "10.1002/(SICI)1099-1409(200003)4:2<185::AID-JPP179>3.0.CO;2-I",

language = "English",

volume = "4",

pages = "185--191",

journal = "Journal of Porphyrins and Phthalocyanines",

issn = "1088-4246",

publisher = "World Scientific",

number = "2",

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T1 - Synthesis of the 6,7-bis[2-methoxycarbonyl(1,1-dideutero)ethyl] derivative of protoporphyrin IX dimethyl ester

AU - Shim, Young Key

AU - Pandey, Ravindra K.

AU - Smith, Kevin M.

PY - 2000/3

Y1 - 2000/3

N2 - A new total synthesis of a protoporphyrin IX derivative in which the α-methylene protons of the 13,17-(2-methoxycarbonylethyl) substituents are regioselectively deuterated is described. The deuterated porphyrin was obtained using the oxidative cyclization of an a, c-biladiene dihydrobromide. Copyright (C) 2000 John Wiley and Sons, Ltd.

AB - A new total synthesis of a protoporphyrin IX derivative in which the α-methylene protons of the 13,17-(2-methoxycarbonylethyl) substituents are regioselectively deuterated is described. The deuterated porphyrin was obtained using the oxidative cyclization of an a, c-biladiene dihydrobromide. Copyright (C) 2000 John Wiley and Sons, Ltd.

KW - a, c-biladienes

KW - Deuterium labeling

KW - Heme proteins

KW - Porphyrin synthesis

UR - https://www.scopus.com/pages/publications/0033646607

U2 - 10.1002/(SICI)1099-1409(200003)4:2<185::AID-JPP179>3.0.CO;2-I

DO - 10.1002/(SICI)1099-1409(200003)4:2<185::AID-JPP179>3.0.CO;2-I

M3 - Article

AN - SCOPUS:0033646607

SN - 1088-4246

VL - 4

SP - 185

EP - 191

JO - Journal of Porphyrins and Phthalocyanines

JF - Journal of Porphyrins and Phthalocyanines

IS - 2

ER -

Synthesis of the 6,7-bis[2-methoxycarbonyl(1,1-dideutero)ethyl] derivative of protoporphyrin IX dimethyl ester

Abstract

Keywords

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