Synthesis of 15O-labeled butanol via organoborane chemistry

G. W. Kabalka; R. M. Lambrecht; M. Sajjad; J. S. Fowler; S. A. Kunda; G. W. McCollum; R. MacGregor

doi:10.1016/0020-708X(85)90017-1

Synthesis of ¹⁵O-labeled butanol via organoborane chemistry

G. W. Kabalka
, R. M. Lambrecht
, M. Sajjad
, J. S. Fowler
, S. A. Kunda
, G. W. McCollum
, R. MacGregor

Radiology

University of Tennessee
Brookhaven National Laboratory

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Oxygen-15 labeled 1-butanol and 2-butanol were prepared by the reaction of O₂-¹⁵O with tri-n-butylborane and tri-sec-butylborane in tetrahydrofuran. The reaction products were isolated and identified via reversed-phase high performance column chromatography and gas chromatography. Radiochemical yields of 50% (EOB) were obtained. The use of ¹⁵O-labeled butanol is suggested for cerebral blood flow measurements in conjunction with PET.

Original language	English
Pages (from-to)	853-855
Number of pages	3
Journal	International Journal of Applied Radiation and Isotopes
Volume	36
Issue number	11
DOIs	https://doi.org/10.1016/0020-708X(85)90017-1
State	Published - Nov 1985

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10.1016/0020-708X(85)90017-1

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title = "Synthesis of 15O-labeled butanol via organoborane chemistry",

abstract = "Oxygen-15 labeled 1-butanol and 2-butanol were prepared by the reaction of O2-15O with tri-n-butylborane and tri-sec-butylborane in tetrahydrofuran. The reaction products were isolated and identified via reversed-phase high performance column chromatography and gas chromatography. Radiochemical yields of 50\% (EOB) were obtained. The use of 15O-labeled butanol is suggested for cerebral blood flow measurements in conjunction with PET.",

author = "Kabalka, \{G. W.\} and Lambrecht, \{R. M.\} and M. Sajjad and Fowler, \{J. S.\} and Kunda, \{S. A.\} and McCollum, \{G. W.\} and R. MacGregor",

year = "1985",

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doi = "10.1016/0020-708X(85)90017-1",

language = "English",

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journal = "International Journal of Applied Radiation and Isotopes",

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TY - JOUR

T1 - Synthesis of 15O-labeled butanol via organoborane chemistry

AU - Kabalka, G. W.

AU - Lambrecht, R. M.

AU - Sajjad, M.

AU - Fowler, J. S.

AU - Kunda, S. A.

AU - McCollum, G. W.

AU - MacGregor, R.

PY - 1985/11

Y1 - 1985/11

N2 - Oxygen-15 labeled 1-butanol and 2-butanol were prepared by the reaction of O2-15O with tri-n-butylborane and tri-sec-butylborane in tetrahydrofuran. The reaction products were isolated and identified via reversed-phase high performance column chromatography and gas chromatography. Radiochemical yields of 50% (EOB) were obtained. The use of 15O-labeled butanol is suggested for cerebral blood flow measurements in conjunction with PET.

AB - Oxygen-15 labeled 1-butanol and 2-butanol were prepared by the reaction of O2-15O with tri-n-butylborane and tri-sec-butylborane in tetrahydrofuran. The reaction products were isolated and identified via reversed-phase high performance column chromatography and gas chromatography. Radiochemical yields of 50% (EOB) were obtained. The use of 15O-labeled butanol is suggested for cerebral blood flow measurements in conjunction with PET.

UR - https://www.scopus.com/pages/publications/0022269049

U2 - 10.1016/0020-708X(85)90017-1

DO - 10.1016/0020-708X(85)90017-1

M3 - Article

C2 - 4066058

AN - SCOPUS:0022269049

SN - 0020-708X

VL - 36

SP - 853

EP - 855

JO - International Journal of Applied Radiation and Isotopes

JF - International Journal of Applied Radiation and Isotopes

IS - 11

ER -

Synthesis of ¹⁵O-labeled butanol via organoborane chemistry

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