Synthesis of sulfo and sialyl Lewis(x) analogs with a mannose at the reducing end

Bao Guo Huang; Robert D. Locke; Rakesh K. Jain; Khushi L. Matta

doi:10.1016/S0960-894X(97)00181-9

Synthesis of sulfo and sialyl Lewis(x) analogs with a mannose at the reducing end

Bao Guo Huang
, Robert D. Locke
, Rakesh K. Jain
, Khushi L. Matta

Department of Chemical and Biological Engineering

Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Stereoselective syntheses of 3-O-sulfo and 3-O-sialyl Lewis(x) analogs 1 and 2 were accomplished. Compound 1 showed greater inhibitory activity than the natural ligand sialyl Lewis(x) against P and L-selectin.

Original language	English
Pages (from-to)	1157-1160
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	9
DOIs	https://doi.org/10.1016/S0960-894X(97)00181-9
State	Published - May 6 1997

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title = "Synthesis of sulfo and sialyl Lewis(x) analogs with a mannose at the reducing end",

abstract = "Stereoselective syntheses of 3-O-sulfo and 3-O-sialyl Lewis(x) analogs 1 and 2 were accomplished. Compound 1 showed greater inhibitory activity than the natural ligand sialyl Lewis(x) against P and L-selectin.",

author = "Huang, \{Bao Guo\} and Locke, \{Robert D.\} and Jain, \{Rakesh K.\} and Matta, \{Khushi L.\}",

year = "1997",

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doi = "10.1016/S0960-894X(97)00181-9",

language = "English",

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T1 - Synthesis of sulfo and sialyl Lewis(x) analogs with a mannose at the reducing end

AU - Huang, Bao Guo

AU - Locke, Robert D.

AU - Jain, Rakesh K.

AU - Matta, Khushi L.

PY - 1997/5/6

Y1 - 1997/5/6

N2 - Stereoselective syntheses of 3-O-sulfo and 3-O-sialyl Lewis(x) analogs 1 and 2 were accomplished. Compound 1 showed greater inhibitory activity than the natural ligand sialyl Lewis(x) against P and L-selectin.

AB - Stereoselective syntheses of 3-O-sulfo and 3-O-sialyl Lewis(x) analogs 1 and 2 were accomplished. Compound 1 showed greater inhibitory activity than the natural ligand sialyl Lewis(x) against P and L-selectin.

UR - https://www.scopus.com/pages/publications/0031001530

U2 - 10.1016/S0960-894X(97)00181-9

DO - 10.1016/S0960-894X(97)00181-9

M3 - Article

AN - SCOPUS:0031001530

SN - 0960-894X

VL - 7

SP - 1157

EP - 1160

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 9

ER -

Synthesis of sulfo and sialyl Lewis(x) analogs with a mannose at the reducing end

Abstract

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