Synthesis of novel boron containing unnatural cyclic amino acids as potential therapeutic agents

George W. Kabalka; Bhaskar C. Das; Sasmita Das

doi:10.1016/S0040-4039(01)01486-1

Synthesis of novel boron containing unnatural cyclic amino acids as potential therapeutic agents

George W. Kabalka
, Bhaskar C. Das
, Sasmita Das

Pharmaceutical Sciences

University of Tennessee

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Two boronated α-amino acids, 1-amino-3-boronocyclopentanecarboxylic acid and 1-amino-3-boronocycloheptanecarboxylic acid were prepared. The key step in the syntheses was the 1,4-boration of the α,β-unsaturated cyclic ketones using the bis-pinacolatodiboron ester to generate the boronated ketones which were then converted to the corresponding amino acids.

Original language	English
Pages (from-to)	7145-7146
Number of pages	2
Journal	Tetrahedron Letters
Volume	42
Issue number	41
DOIs	https://doi.org/10.1016/S0040-4039(01)01486-1
State	Published - Oct 8 2001

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title = "Synthesis of novel boron containing unnatural cyclic amino acids as potential therapeutic agents",

abstract = "Two boronated α-amino acids, 1-amino-3-boronocyclopentanecarboxylic acid and 1-amino-3-boronocycloheptanecarboxylic acid were prepared. The key step in the syntheses was the 1,4-boration of the α,β-unsaturated cyclic ketones using the bis-pinacolatodiboron ester to generate the boronated ketones which were then converted to the corresponding amino acids.",

author = "Kabalka, \{George W.\} and Das, \{Bhaskar C.\} and Sasmita Das",

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journal = "Tetrahedron Letters",

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T1 - Synthesis of novel boron containing unnatural cyclic amino acids as potential therapeutic agents

AU - Kabalka, George W.

AU - Das, Bhaskar C.

AU - Das, Sasmita

PY - 2001/10/8

Y1 - 2001/10/8

N2 - Two boronated α-amino acids, 1-amino-3-boronocyclopentanecarboxylic acid and 1-amino-3-boronocycloheptanecarboxylic acid were prepared. The key step in the syntheses was the 1,4-boration of the α,β-unsaturated cyclic ketones using the bis-pinacolatodiboron ester to generate the boronated ketones which were then converted to the corresponding amino acids.

AB - Two boronated α-amino acids, 1-amino-3-boronocyclopentanecarboxylic acid and 1-amino-3-boronocycloheptanecarboxylic acid were prepared. The key step in the syntheses was the 1,4-boration of the α,β-unsaturated cyclic ketones using the bis-pinacolatodiboron ester to generate the boronated ketones which were then converted to the corresponding amino acids.

UR - https://www.scopus.com/pages/publications/0035829104

U2 - 10.1016/S0040-4039(01)01486-1

DO - 10.1016/S0040-4039(01)01486-1

M3 - Article

AN - SCOPUS:0035829104

SN - 0040-4039

VL - 42

SP - 7145

EP - 7146

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 41

ER -

Synthesis of novel boron containing unnatural cyclic amino acids as potential therapeutic agents

Abstract

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