Abstract
Quick as a flash! A series of conformationally constrained, macrocyclic tetrazoles were expediently prepared by double alkylation of a bis(o-phenolyl)tetrazole precursor. Several of them showed excellent reactivity toward norbornene in a photoinduced tetrazole-alkene cycloaddition reaction in organic solvent, as well as toward a norbornene-modified protein in phosphate-buffered saline buffer (see scheme).
| Original language | English |
|---|---|
| Pages (from-to) | 13325-13329 |
| Number of pages | 5 |
| Journal | Chemistry - A European Journal |
| Volume | 16 |
| Issue number | 45 |
| DOIs | |
| State | Published - Dec 3 2010 |
Keywords
- alkenes
- bioorthogonal chemistry
- biotechnology
- cycloaddition
- tetrazoles
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