Synthesis of Cyclosporin A-Derived Affinity Reagents by Olefin Metathesis

Jason A. Smulik; Steven T. Diver; Fan Pan; Jun O. Liu

doi:10.1021/ol0258987

Synthesis of Cyclosporin A-Derived Affinity Reagents by Olefin Metathesis

Jason A. Smulik
, Steven T. Diver
, Fan Pan
, Jun O. Liu

Chemistry

SUNY Buffalo
Johns Hopkins University

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

(Matrix Presented) New affinity reagents were synthesized using alkene metathesis to directly modify the MeBmt side chain of cyclosporin A. The reagents were used to detect novel cyclophilins from cellular extracts.

Original language	English
Pages (from-to)	2051-2054
Number of pages	4
Journal	Organic Letters
Volume	4
Issue number	12
DOIs	https://doi.org/10.1021/ol0258987
State	Published - Jun 13 2002

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10.1021/ol0258987

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@article{98c8a0d9194648a0894cc2b538a9a839,

title = "Synthesis of Cyclosporin A-Derived Affinity Reagents by Olefin Metathesis",

abstract = "(Matrix Presented) New affinity reagents were synthesized using alkene metathesis to directly modify the MeBmt side chain of cyclosporin A. The reagents were used to detect novel cyclophilins from cellular extracts.",

author = "Smulik, \{Jason A.\} and Diver, \{Steven T.\} and Fan Pan and Liu, \{Jun O.\}",

year = "2002",

month = jun,

day = "13",

doi = "10.1021/ol0258987",

language = "English",

volume = "4",

pages = "2051--2054",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "12",

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TY - JOUR

T1 - Synthesis of Cyclosporin A-Derived Affinity Reagents by Olefin Metathesis

AU - Smulik, Jason A.

AU - Diver, Steven T.

AU - Pan, Fan

AU - Liu, Jun O.

PY - 2002/6/13

Y1 - 2002/6/13

N2 - (Matrix Presented) New affinity reagents were synthesized using alkene metathesis to directly modify the MeBmt side chain of cyclosporin A. The reagents were used to detect novel cyclophilins from cellular extracts.

AB - (Matrix Presented) New affinity reagents were synthesized using alkene metathesis to directly modify the MeBmt side chain of cyclosporin A. The reagents were used to detect novel cyclophilins from cellular extracts.

UR - https://www.scopus.com/pages/publications/0037071939

U2 - 10.1021/ol0258987

DO - 10.1021/ol0258987

M3 - Article

C2 - 12049515

AN - SCOPUS:0037071939

SN - 1523-7060

VL - 4

SP - 2051

EP - 2054

JO - Organic Letters

JF - Organic Letters

IS - 12

ER -

Synthesis of Cyclosporin A-Derived Affinity Reagents by Olefin Metathesis

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