Synthesis of 8-Methoxy-15, 16-dinor-6, 8, 10-Trichothecatriene 12, 13α-Epoxide and 12, 13β-Epoxide as Potential Antineoplastic Agents

Wayne K. Anderson; George E. Lee

doi:10.1021/jm00175a021

Synthesis of 8-Methoxy-15, 16-dinor-6, 8, 10-Trichothecatriene 12, 13α-Epoxide and 12, 13β-Epoxide as Potential Antineoplastic Agents

Wayne K. Anderson
, George E. Lee

Pharmaceutical Sciences

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

8-Methoxy-15, 16-dinor-6, 8, 10-trichothecatriene 12, 13α-epoxide (5) and 12, 13β-epoxide (3) were prepared; the stereochemistry of the epoxides was assigned on the basis of ¹³C NMR. The epoxide 5 was active against 9KB in vitro and P388 in vivo, while the isomeric epoxide 3 was inactive in both test systems.

Original language	English
Pages (from-to)	96-97
Number of pages	2
Journal	Journal of Medicinal Chemistry
Volume	23
Issue number	1
DOIs	https://doi.org/10.1021/jm00175a021
State	Published - Jan 1 1980

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title = "Synthesis of 8-Methoxy-15, 16-dinor-6, 8, 10-Trichothecatriene 12, 13α-Epoxide and 12, 13β-Epoxide as Potential Antineoplastic Agents",

abstract = "8-Methoxy-15, 16-dinor-6, 8, 10-trichothecatriene 12, 13α-epoxide (5) and 12, 13β-epoxide (3) were prepared; the stereochemistry of the epoxides was assigned on the basis of 13C NMR. The epoxide 5 was active against 9KB in vitro and P388 in vivo, while the isomeric epoxide 3 was inactive in both test systems.",

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AU - Lee, George E.

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Y1 - 1980/1/1

N2 - 8-Methoxy-15, 16-dinor-6, 8, 10-trichothecatriene 12, 13α-epoxide (5) and 12, 13β-epoxide (3) were prepared; the stereochemistry of the epoxides was assigned on the basis of 13C NMR. The epoxide 5 was active against 9KB in vitro and P388 in vivo, while the isomeric epoxide 3 was inactive in both test systems.

AB - 8-Methoxy-15, 16-dinor-6, 8, 10-trichothecatriene 12, 13α-epoxide (5) and 12, 13β-epoxide (3) were prepared; the stereochemistry of the epoxides was assigned on the basis of 13C NMR. The epoxide 5 was active against 9KB in vitro and P388 in vivo, while the isomeric epoxide 3 was inactive in both test systems.

UR - https://www.scopus.com/pages/publications/0018882023

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DO - 10.1021/jm00175a021

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Synthesis of 8-Methoxy-15, 16-dinor-6, 8, 10-Trichothecatriene 12, 13α-Epoxide and 12, 13β-Epoxide as Potential Antineoplastic Agents

Abstract

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