Synthesis of 4-Formyl-4-imidazolin-2-one Nucleosides, Isomers of Uridine and 2′-Deoxyuridine

Xiang Jun Jiang; Thomas I. Kalman

doi:10.1081/NCN-120027837

Synthesis of 4-Formyl-4-imidazolin-2-one Nucleosides, Isomers of Uridine and 2′-Deoxyuridine

Xiang Jun Jiang
, Thomas I. Kalman

Chemistry

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The syntheses of the ribo- and deoxyribonucleoside derivatives of 4-formyl-4-imidazolin-2-one, isosteric isomers of uridine and 2‰-deoxyuridine, respectively, were carried out by ring contraction of the corresponding 5-bromouracil nucleosides, followed by conversion of the carboxyl side-chain of the products to the respective carboxaldehyde derivatives.

Original language	English
Pages (from-to)	307-316
Number of pages	10
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	23
Issue number	1-2
DOIs	https://doi.org/10.1081/NCN-120027837
State	Published - 2004

Keywords

2′-Deoxyuridine
Nucleosides
Uridine

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10.1081/NCN-120027837

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title = "Synthesis of 4-Formyl-4-imidazolin-2-one Nucleosides, Isomers of Uridine and 2′-Deoxyuridine",

abstract = "The syntheses of the ribo- and deoxyribonucleoside derivatives of 4-formyl-4-imidazolin-2-one, isosteric isomers of uridine and 2‰-deoxyuridine, respectively, were carried out by ring contraction of the corresponding 5-bromouracil nucleosides, followed by conversion of the carboxyl side-chain of the products to the respective carboxaldehyde derivatives.",

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AU - Jiang, Xiang Jun

AU - Kalman, Thomas I.

PY - 2004

Y1 - 2004

N2 - The syntheses of the ribo- and deoxyribonucleoside derivatives of 4-formyl-4-imidazolin-2-one, isosteric isomers of uridine and 2‰-deoxyuridine, respectively, were carried out by ring contraction of the corresponding 5-bromouracil nucleosides, followed by conversion of the carboxyl side-chain of the products to the respective carboxaldehyde derivatives.

AB - The syntheses of the ribo- and deoxyribonucleoside derivatives of 4-formyl-4-imidazolin-2-one, isosteric isomers of uridine and 2‰-deoxyuridine, respectively, were carried out by ring contraction of the corresponding 5-bromouracil nucleosides, followed by conversion of the carboxyl side-chain of the products to the respective carboxaldehyde derivatives.

KW - 2′-Deoxyuridine

KW - Nucleosides

KW - Uridine

UR - https://www.scopus.com/pages/publications/1542784388

U2 - 10.1081/NCN-120027837

DO - 10.1081/NCN-120027837

M3 - Article

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AN - SCOPUS:1542784388

SN - 1525-7770

VL - 23

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JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 1-2

ER -

Synthesis of 4-Formyl-4-imidazolin-2-one Nucleosides, Isomers of Uridine and 2′-Deoxyuridine

Abstract

Keywords

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