Synthesis of 2-[123I and 124I]-iodoisonicotinic acid hydrazide-potential radiotracers for tuberculosis

C. W. Somawardhana; M. Sajjad; J. K. Amartey; R. M. Lambrecht

doi:10.1016/0883-2889(91)90079-G

Synthesis of 2-[¹²³I and ¹²⁴I]-iodoisonicotinic acid hydrazide-potential radiotracers for tuberculosis

C. W. Somawardhana
, M. Sajjad
, J. K. Amartey
, R. M. Lambrecht

Radiology

King Faisal Specialist Hospital and Research Centre

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The radiochemical syntheses of methyl 2-[¹²³I]-iodoisonicotinate, 2-[¹²³I]-iodoisonicotinic acid hydrazide and 2-[¹²⁴I]-iodoisonicotinic acid hydrazide was accomplished. Iodine-123 was incorporated in the methyl ester molecule by an exchange reaction in glacial acetic acid. The average efficiency of iodine exchange reaction was (92.6 ± 4.5)%. This radiotracer was extracted with ether and the solvent was evaporated. The residue was re-dissolved in anhydrous ethanol and treated with hydrazine under anhydrous conditions to obtain 2-[¹²³I]-iodoisonicotinic acid hydrazide. The overall radiochemical yield was 69%. Biodistribution data of both radio-tracers in male Sprague-Dawley rats were collected. This is the first report of SPECT radiopharmaceuticals which may be useful for differential diagnosis of intracranial masses (tuberculoma vs glioma), and CNS tuberculosis in immunosuppressed subjects.

Original language	English
Pages (from-to)	215-220
Number of pages	6
Journal	International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes
Volume	42
Issue number	3
DOIs	https://doi.org/10.1016/0883-2889(91)90079-G
State	Published - 1991

Access to Document

10.1016/0883-2889(91)90079-G

Cite this

@article{3047362b2b584f99a104b013fff1df90,

title = "Synthesis of 2-[123I and 124I]-iodoisonicotinic acid hydrazide-potential radiotracers for tuberculosis",

abstract = "The radiochemical syntheses of methyl 2-[123I]-iodoisonicotinate, 2-[123I]-iodoisonicotinic acid hydrazide and 2-[124I]-iodoisonicotinic acid hydrazide was accomplished. Iodine-123 was incorporated in the methyl ester molecule by an exchange reaction in glacial acetic acid. The average efficiency of iodine exchange reaction was (92.6 ± 4.5)\%. This radiotracer was extracted with ether and the solvent was evaporated. The residue was re-dissolved in anhydrous ethanol and treated with hydrazine under anhydrous conditions to obtain 2-[123I]-iodoisonicotinic acid hydrazide. The overall radiochemical yield was 69\%. Biodistribution data of both radio-tracers in male Sprague-Dawley rats were collected. This is the first report of SPECT radiopharmaceuticals which may be useful for differential diagnosis of intracranial masses (tuberculoma vs glioma), and CNS tuberculosis in immunosuppressed subjects.",

author = "Somawardhana, \{C. W.\} and M. Sajjad and Amartey, \{J. K.\} and Lambrecht, \{R. M.\}",

year = "1991",

doi = "10.1016/0883-2889(91)90079-G",

language = "English",

volume = "42",

pages = "215--220",

journal = "International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes",

issn = "0883-2889",

publisher = "Pergamon Press Ltd.",

number = "3",

}

Synthesis of 2-[¹²³I and ¹²⁴I]-iodoisonicotinic acid hydrazide-potential radiotracers for tuberculosis. / Somawardhana, C. W.; Sajjad, M.; Amartey, J. K. et al.
In: International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, Vol. 42, No. 3, 1991, p. 215-220.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis of 2-[123I and 124I]-iodoisonicotinic acid hydrazide-potential radiotracers for tuberculosis

AU - Somawardhana, C. W.

AU - Sajjad, M.

AU - Amartey, J. K.

AU - Lambrecht, R. M.

PY - 1991

Y1 - 1991

N2 - The radiochemical syntheses of methyl 2-[123I]-iodoisonicotinate, 2-[123I]-iodoisonicotinic acid hydrazide and 2-[124I]-iodoisonicotinic acid hydrazide was accomplished. Iodine-123 was incorporated in the methyl ester molecule by an exchange reaction in glacial acetic acid. The average efficiency of iodine exchange reaction was (92.6 ± 4.5)%. This radiotracer was extracted with ether and the solvent was evaporated. The residue was re-dissolved in anhydrous ethanol and treated with hydrazine under anhydrous conditions to obtain 2-[123I]-iodoisonicotinic acid hydrazide. The overall radiochemical yield was 69%. Biodistribution data of both radio-tracers in male Sprague-Dawley rats were collected. This is the first report of SPECT radiopharmaceuticals which may be useful for differential diagnosis of intracranial masses (tuberculoma vs glioma), and CNS tuberculosis in immunosuppressed subjects.

AB - The radiochemical syntheses of methyl 2-[123I]-iodoisonicotinate, 2-[123I]-iodoisonicotinic acid hydrazide and 2-[124I]-iodoisonicotinic acid hydrazide was accomplished. Iodine-123 was incorporated in the methyl ester molecule by an exchange reaction in glacial acetic acid. The average efficiency of iodine exchange reaction was (92.6 ± 4.5)%. This radiotracer was extracted with ether and the solvent was evaporated. The residue was re-dissolved in anhydrous ethanol and treated with hydrazine under anhydrous conditions to obtain 2-[123I]-iodoisonicotinic acid hydrazide. The overall radiochemical yield was 69%. Biodistribution data of both radio-tracers in male Sprague-Dawley rats were collected. This is the first report of SPECT radiopharmaceuticals which may be useful for differential diagnosis of intracranial masses (tuberculoma vs glioma), and CNS tuberculosis in immunosuppressed subjects.

UR - https://www.scopus.com/pages/publications/0026081920

U2 - 10.1016/0883-2889(91)90079-G

DO - 10.1016/0883-2889(91)90079-G

M3 - Article

C2 - 1647381

AN - SCOPUS:0026081920

SN - 0883-2889

VL - 42

SP - 215

EP - 220

JO - International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes

JF - International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes

IS - 3

ER -

Synthesis of 2-[¹²³I and ¹²⁴I]-iodoisonicotinic acid hydrazide-potential radiotracers for tuberculosis

Abstract

Access to Document

Other files and links

Fingerprint

Cite this