Synthesis of 2-substituted 2H-chromenes using potassium vinyltrifluoroborates

Fei Liu; Todd Evans; Bhaskar C. Das

doi:10.1016/j.tetlet.2008.01.008

Synthesis of 2-substituted 2H-chromenes using potassium vinyltrifluoroborates

Fei Liu
, Todd Evans
, Bhaskar C. Das

Pharmaceutical Sciences

Albert Einstein College of Medicine

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

2H-Chromenes were synthesized from salicylaldehyde using potassium vinylic borates in the presence of secondary amines. We synthesized these 2H-chromene derivatives as a part of an ongoing project to develop inhibitors for TGF-β receptors. Potassium vinyl trifluoroborates react with salicylaldehydes at 80 °C in the presence of a secondary amine and produced 2-substituted 2H-chromene derivatives with a 70-90% yield.

Original language	English
Pages (from-to)	1578-1581
Number of pages	4
Journal	Tetrahedron Letters
Volume	49
Issue number	10
DOIs	https://doi.org/10.1016/j.tetlet.2008.01.008
State	Published - Mar 3 2008

Keywords

Chromenes
Potassium organic trifluoroborate
Signal transduction
TGF-β inhibitors

Access to Document

10.1016/j.tetlet.2008.01.008

Cite this

@article{d9a66ac8ef474e57b8c23d976b7c49e3,

title = "Synthesis of 2-substituted 2H-chromenes using potassium vinyltrifluoroborates",

abstract = "2H-Chromenes were synthesized from salicylaldehyde using potassium vinylic borates in the presence of secondary amines. We synthesized these 2H-chromene derivatives as a part of an ongoing project to develop inhibitors for TGF-β receptors. Potassium vinyl trifluoroborates react with salicylaldehydes at 80 °C in the presence of a secondary amine and produced 2-substituted 2H-chromene derivatives with a 70-90\% yield.",

keywords = "Chromenes, Potassium organic trifluoroborate, Signal transduction, TGF-β inhibitors",

author = "Fei Liu and Todd Evans and Das, \{Bhaskar C.\}",

year = "2008",

month = mar,

day = "3",

doi = "10.1016/j.tetlet.2008.01.008",

language = "English",

volume = "49",

pages = "1578--1581",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "10",

}

TY - JOUR

T1 - Synthesis of 2-substituted 2H-chromenes using potassium vinyltrifluoroborates

AU - Liu, Fei

AU - Evans, Todd

AU - Das, Bhaskar C.

PY - 2008/3/3

Y1 - 2008/3/3

N2 - 2H-Chromenes were synthesized from salicylaldehyde using potassium vinylic borates in the presence of secondary amines. We synthesized these 2H-chromene derivatives as a part of an ongoing project to develop inhibitors for TGF-β receptors. Potassium vinyl trifluoroborates react with salicylaldehydes at 80 °C in the presence of a secondary amine and produced 2-substituted 2H-chromene derivatives with a 70-90% yield.

AB - 2H-Chromenes were synthesized from salicylaldehyde using potassium vinylic borates in the presence of secondary amines. We synthesized these 2H-chromene derivatives as a part of an ongoing project to develop inhibitors for TGF-β receptors. Potassium vinyl trifluoroborates react with salicylaldehydes at 80 °C in the presence of a secondary amine and produced 2-substituted 2H-chromene derivatives with a 70-90% yield.

KW - Chromenes

KW - Potassium organic trifluoroborate

KW - Signal transduction

KW - TGF-β inhibitors

UR - https://www.scopus.com/pages/publications/38949214649

U2 - 10.1016/j.tetlet.2008.01.008

DO - 10.1016/j.tetlet.2008.01.008

M3 - Article

AN - SCOPUS:38949214649

SN - 0040-4039

VL - 49

SP - 1578

EP - 1581

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 10

ER -

Synthesis of 2-substituted 2H-chromenes using potassium vinyltrifluoroborates

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this