Synthesis and cytotoxic activity of A-ring modified betulinic acid derivatives

Young Jae You; Yong Kim; Nguyen Hai Nam; Byung Zun Ahn

doi:10.1016/S0960-894X(03)00724-8

Synthesis and cytotoxic activity of A-ring modified betulinic acid derivatives

Young Jae You
, Yong Kim
, Nguyen Hai Nam
, Byung Zun Ahn

Pharmaceutical Sciences

Chungnam National University
SB Pharmaceutical Company

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

New A-ring modified betulinic acid derivatives having small steric hindrance were prepared and tested for cytotoxic activity on 3 cancer cell lines: 10 compounds showed stronger cytotoxic activity than betulinic acid. Especially, the compounds bearing 1-ene-3-oxo with electron-withdrawing groups at C2 showed strong cytotoxicity.

Original language	English
Pages (from-to)	3137-3140
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	19
DOIs	https://doi.org/10.1016/S0960-894X(03)00724-8
State	Published - Oct 16 2003

Access to Document

10.1016/S0960-894X(03)00724-8

Cite this

@article{96d62891e2294c67801620be2a282821,

title = "Synthesis and cytotoxic activity of A-ring modified betulinic acid derivatives",

abstract = "New A-ring modified betulinic acid derivatives having small steric hindrance were prepared and tested for cytotoxic activity on 3 cancer cell lines: 10 compounds showed stronger cytotoxic activity than betulinic acid. Especially, the compounds bearing 1-ene-3-oxo with electron-withdrawing groups at C2 showed strong cytotoxicity.",

author = "You, \{Young Jae\} and Yong Kim and Nam, \{Nguyen Hai\} and Ahn, \{Byung Zun\}",

year = "2003",

month = oct,

day = "16",

doi = "10.1016/S0960-894X(03)00724-8",

language = "English",

volume = "13",

pages = "3137--3140",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "19",

}

TY - JOUR

T1 - Synthesis and cytotoxic activity of A-ring modified betulinic acid derivatives

AU - You, Young Jae

AU - Kim, Yong

AU - Nam, Nguyen Hai

AU - Ahn, Byung Zun

PY - 2003/10/16

Y1 - 2003/10/16

N2 - New A-ring modified betulinic acid derivatives having small steric hindrance were prepared and tested for cytotoxic activity on 3 cancer cell lines: 10 compounds showed stronger cytotoxic activity than betulinic acid. Especially, the compounds bearing 1-ene-3-oxo with electron-withdrawing groups at C2 showed strong cytotoxicity.

AB - New A-ring modified betulinic acid derivatives having small steric hindrance were prepared and tested for cytotoxic activity on 3 cancer cell lines: 10 compounds showed stronger cytotoxic activity than betulinic acid. Especially, the compounds bearing 1-ene-3-oxo with electron-withdrawing groups at C2 showed strong cytotoxicity.

UR - https://www.scopus.com/pages/publications/0041831050

U2 - 10.1016/S0960-894X(03)00724-8

DO - 10.1016/S0960-894X(03)00724-8

M3 - Article

C2 - 12951080

AN - SCOPUS:0041831050

SN - 0960-894X

VL - 13

SP - 3137

EP - 3140

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 19

ER -

Synthesis and cytotoxic activity of A-ring modified betulinic acid derivatives

Abstract

Access to Document

Other files and links

Fingerprint

Cite this