Synthesis and binding properties of 2H-1-benzopyran-2 one fluorophore-linked calcium channel antagonist nifedipine (1,4-dihydropyridine) analogs

Seetharamaiyer Padmanabhan; Ravikumar Peri; Aleta Rutledge; David J. Triggle

doi:10.1002/jhet.5570340146

Synthesis and binding properties of 2H-1-benzopyran-2 one fluorophore-linked calcium channel antagonist nifedipine (1,4-dihydropyridine) analogs

Seetharamaiyer Padmanabhan
, Ravikumar Peri
, Aleta Rutledge
, David J. Triggle

School of Pharmacy and Pharmaceutical Sciences

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Nifedipine analogs I, II and III with the 2H-1-benzopyran-2-one (coumarin) fluorophore linked at the 2, 2 and 6 and 4 positions of the dihydropyridine ring were synthesized by the modified Hantzch condensation procedures. Attempts to synthesize dihydropyridine with the fluorophore at position 3 (IV) were unsuccessful.

Original language	English
Pages (from-to)	301-304
Number of pages	4
Journal	Journal of Heterocyclic Chemistry
Volume	34
Issue number	1
DOIs	https://doi.org/10.1002/jhet.5570340146
State	Published - 1997

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title = "Synthesis and binding properties of 2H-1-benzopyran-2 one fluorophore-linked calcium channel antagonist nifedipine (1,4-dihydropyridine) analogs",

abstract = "Nifedipine analogs I, II and III with the 2H-1-benzopyran-2-one (coumarin) fluorophore linked at the 2, 2 and 6 and 4 positions of the dihydropyridine ring were synthesized by the modified Hantzch condensation procedures. Attempts to synthesize dihydropyridine with the fluorophore at position 3 (IV) were unsuccessful.",

author = "Seetharamaiyer Padmanabhan and Ravikumar Peri and Aleta Rutledge and Triggle, \{David J.\}",

year = "1997",

doi = "10.1002/jhet.5570340146",

language = "English",

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pages = "301--304",

journal = "Journal of Heterocyclic Chemistry",

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T1 - Synthesis and binding properties of 2H-1-benzopyran-2 one fluorophore-linked calcium channel antagonist nifedipine (1,4-dihydropyridine) analogs

AU - Padmanabhan, Seetharamaiyer

AU - Peri, Ravikumar

AU - Rutledge, Aleta

AU - Triggle, David J.

PY - 1997

Y1 - 1997

N2 - Nifedipine analogs I, II and III with the 2H-1-benzopyran-2-one (coumarin) fluorophore linked at the 2, 2 and 6 and 4 positions of the dihydropyridine ring were synthesized by the modified Hantzch condensation procedures. Attempts to synthesize dihydropyridine with the fluorophore at position 3 (IV) were unsuccessful.

AB - Nifedipine analogs I, II and III with the 2H-1-benzopyran-2-one (coumarin) fluorophore linked at the 2, 2 and 6 and 4 positions of the dihydropyridine ring were synthesized by the modified Hantzch condensation procedures. Attempts to synthesize dihydropyridine with the fluorophore at position 3 (IV) were unsuccessful.

UR - https://www.scopus.com/pages/publications/0030888949

U2 - 10.1002/jhet.5570340146

DO - 10.1002/jhet.5570340146

M3 - Article

AN - SCOPUS:0030888949

SN - 0022-152X

VL - 34

SP - 301

EP - 304

JO - Journal of Heterocyclic Chemistry

JF - Journal of Heterocyclic Chemistry

IS - 1

ER -

Synthesis and binding properties of 2H-1-benzopyran-2 one fluorophore-linked calcium channel antagonist nifedipine (1,4-dihydropyridine) analogs

Abstract

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