Synthesis and antineoplastic activity of quinoline derivatives

Qiang Zhou; Jing Hou; Huamin Li; Li Cui; Han Jia; Bing Gong; Lan He

doi:10.1071/CH07419

Synthesis and antineoplastic activity of quinoline derivatives

Qiang Zhou
, Jing Hou
, Huamin Li
, Li Cui
, Han Jia
, Bing Gong
, Lan He

Chemistry

Beijing Normal University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Designed as a new series of molecules that contain the quinoline substructure, several 11H-indolo[3.2-c]quinoline derivatives were synthesized and subjected to biological evaluation. Several compounds were found to exhibit cytotoxic activity against the growth of colon (HTC-8), liver (BEL-7402), gastric (BCG-823), pulmonary gland (A549), and ovary (A2780) cancer cell lines. The structureactivity relationship of these compounds is discussed.

Original language	English
Pages (from-to)	531-536
Number of pages	6
Journal	Australian Journal of Chemistry
Volume	61
Issue number	7
DOIs	https://doi.org/10.1071/CH07419
State	Published - 2008

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title = "Synthesis and antineoplastic activity of quinoline derivatives",

abstract = "Designed as a new series of molecules that contain the quinoline substructure, several 11H-indolo[3.2-c]quinoline derivatives were synthesized and subjected to biological evaluation. Several compounds were found to exhibit cytotoxic activity against the growth of colon (HTC-8), liver (BEL-7402), gastric (BCG-823), pulmonary gland (A549), and ovary (A2780) cancer cell lines. The structureactivity relationship of these compounds is discussed.",

author = "Qiang Zhou and Jing Hou and Huamin Li and Li Cui and Han Jia and Bing Gong and Lan He",

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doi = "10.1071/CH07419",

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journal = "Australian Journal of Chemistry",

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T1 - Synthesis and antineoplastic activity of quinoline derivatives

AU - Zhou, Qiang

AU - Hou, Jing

AU - Li, Huamin

AU - Cui, Li

AU - Jia, Han

AU - Gong, Bing

AU - He, Lan

PY - 2008

Y1 - 2008

N2 - Designed as a new series of molecules that contain the quinoline substructure, several 11H-indolo[3.2-c]quinoline derivatives were synthesized and subjected to biological evaluation. Several compounds were found to exhibit cytotoxic activity against the growth of colon (HTC-8), liver (BEL-7402), gastric (BCG-823), pulmonary gland (A549), and ovary (A2780) cancer cell lines. The structureactivity relationship of these compounds is discussed.

AB - Designed as a new series of molecules that contain the quinoline substructure, several 11H-indolo[3.2-c]quinoline derivatives were synthesized and subjected to biological evaluation. Several compounds were found to exhibit cytotoxic activity against the growth of colon (HTC-8), liver (BEL-7402), gastric (BCG-823), pulmonary gland (A549), and ovary (A2780) cancer cell lines. The structureactivity relationship of these compounds is discussed.

UR - https://www.scopus.com/pages/publications/47749122597

U2 - 10.1071/CH07419

DO - 10.1071/CH07419

M3 - Article

AN - SCOPUS:47749122597

SN - 0004-9425

VL - 61

SP - 531

EP - 536

JO - Australian Journal of Chemistry

JF - Australian Journal of Chemistry

IS - 7

ER -

Synthesis and antineoplastic activity of quinoline derivatives

Abstract

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