Synthesis and Antileukemic Activity of Fluorinated Analogues of 2,3-Dihydro-5-phenyl-6,7-bis(hydroxymethyl)-1H-pyrrolizine Biscarbamate

Wayne K. Anderson; Howard L. McPherson

doi:10.1021/jm00343a017

Synthesis and Antileukemic Activity of Fluorinated Analogues of 2,3-Dihydro-5-phenyl-6,7-bis(hydroxymethyl)-1H-pyrrolizine Biscarbamate

Wayne K. Anderson
, Howard L. McPherson

Pharmaceutical Sciences

SUNY Buffalo

Research output: Contribution to journal › Comment/debate

22 Scopus citations

Abstract

A series of five difluorophenyl-substituted pyrrolizine biscarbamates was synthesized and evaluated against P388 lymphocytic leukemia. All of the compounds prepared were active, and no significant trends were observed in potency, activity, or toxicity as a function of fluorine substitution.

Original language	English
Pages (from-to)	84-86
Number of pages	3
Journal	Journal of Medicinal Chemistry
Volume	25
Issue number	1
DOIs	https://doi.org/10.1021/jm00343a017
State	Published - 1982

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@article{e648c2325aa04b33b077b661d17d1e38,

title = "Synthesis and Antileukemic Activity of Fluorinated Analogues of 2,3-Dihydro-5-phenyl-6,7-bis(hydroxymethyl)-1H-pyrrolizine Biscarbamate",

abstract = "A series of five difluorophenyl-substituted pyrrolizine biscarbamates was synthesized and evaluated against P388 lymphocytic leukemia. All of the compounds prepared were active, and no significant trends were observed in potency, activity, or toxicity as a function of fluorine substitution.",

author = "Anderson, \{Wayne K.\} and McPherson, \{Howard L.\}",

year = "1982",

doi = "10.1021/jm00343a017",

language = "English",

volume = "25",

pages = "84--86",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

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T1 - Synthesis and Antileukemic Activity of Fluorinated Analogues of 2,3-Dihydro-5-phenyl-6,7-bis(hydroxymethyl)-1H-pyrrolizine Biscarbamate

AU - Anderson, Wayne K.

AU - McPherson, Howard L.

PY - 1982

Y1 - 1982

N2 - A series of five difluorophenyl-substituted pyrrolizine biscarbamates was synthesized and evaluated against P388 lymphocytic leukemia. All of the compounds prepared were active, and no significant trends were observed in potency, activity, or toxicity as a function of fluorine substitution.

AB - A series of five difluorophenyl-substituted pyrrolizine biscarbamates was synthesized and evaluated against P388 lymphocytic leukemia. All of the compounds prepared were active, and no significant trends were observed in potency, activity, or toxicity as a function of fluorine substitution.

UR - https://www.scopus.com/pages/publications/0020056074

U2 - 10.1021/jm00343a017

DO - 10.1021/jm00343a017

M3 - Comment/debate

C2 - 7086826

AN - SCOPUS:0020056074

SN - 0022-2623

VL - 25

SP - 84

EP - 86

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 1

ER -

Synthesis and Antileukemic Activity of Fluorinated Analogues of 2,3-Dihydro-5-phenyl-6,7-bis(hydroxymethyl)-1H-pyrrolizine Biscarbamate

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