Syntheses, stability, and tumorcidal activity of porphyrin dimers and trimers with ether linkages

Ravindra K. Pandey; Fuu Yau Shiau; Craig J. Medforth; Thomas J. Dougherty; Kevin M. Smith

doi:10.1016/S0040-4039(00)88499-3

Syntheses, stability, and tumorcidal activity of porphyrin dimers and trimers with ether linkages

Ravindra K. Pandey
, Fuu Yau Shiau
, Craig J. Medforth
, Thomas J. Dougherty
, Kevin M. Smith

Institute for Lasers Photonics and Biophotonics

University of California at Davis
Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The first syntheses of a series of regiochemically pure porphyrin dimers and trimers with ether linkages which are structurally related to Photofrin-II® are described. Stability of these oligomers was investigated using variable temperature proton NMR spectroscopy, and preliminary biological results reveal that manupulation of peripheral substituents causes a remarkable difference in photosensitizing ability in vivo.

Original language	English
Pages (from-to)	7399-7402
Number of pages	4
Journal	Tetrahedron Letters
Volume	31
Issue number	51
DOIs	https://doi.org/10.1016/S0040-4039(00)88499-3
State	Published - 1990

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title = "Syntheses, stability, and tumorcidal activity of porphyrin dimers and trimers with ether linkages",

abstract = "The first syntheses of a series of regiochemically pure porphyrin dimers and trimers with ether linkages which are structurally related to Photofrin-II{\textregistered} are described. Stability of these oligomers was investigated using variable temperature proton NMR spectroscopy, and preliminary biological results reveal that manupulation of peripheral substituents causes a remarkable difference in photosensitizing ability in vivo.",

author = "Pandey, \{Ravindra K.\} and Shiau, \{Fuu Yau\} and Medforth, \{Craig J.\} and Dougherty, \{Thomas J.\} and Smith, \{Kevin M.\}",

year = "1990",

doi = "10.1016/S0040-4039(00)88499-3",

language = "English",

volume = "31",

pages = "7399--7402",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "51",

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TY - JOUR

T1 - Syntheses, stability, and tumorcidal activity of porphyrin dimers and trimers with ether linkages

AU - Pandey, Ravindra K.

AU - Shiau, Fuu Yau

AU - Medforth, Craig J.

AU - Dougherty, Thomas J.

AU - Smith, Kevin M.

PY - 1990

Y1 - 1990

N2 - The first syntheses of a series of regiochemically pure porphyrin dimers and trimers with ether linkages which are structurally related to Photofrin-II® are described. Stability of these oligomers was investigated using variable temperature proton NMR spectroscopy, and preliminary biological results reveal that manupulation of peripheral substituents causes a remarkable difference in photosensitizing ability in vivo.

AB - The first syntheses of a series of regiochemically pure porphyrin dimers and trimers with ether linkages which are structurally related to Photofrin-II® are described. Stability of these oligomers was investigated using variable temperature proton NMR spectroscopy, and preliminary biological results reveal that manupulation of peripheral substituents causes a remarkable difference in photosensitizing ability in vivo.

UR - https://www.scopus.com/pages/publications/0025603194

U2 - 10.1016/S0040-4039(00)88499-3

DO - 10.1016/S0040-4039(00)88499-3

M3 - Article

AN - SCOPUS:0025603194

SN - 0040-4039

VL - 31

SP - 7399

EP - 7402

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 51

ER -

Syntheses, stability, and tumorcidal activity of porphyrin dimers and trimers with ether linkages

Abstract

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