Syntheses of stable bacteriochlorophyll-a derivatives as potential photosensitizers for photodynamic therapy

Andrei N. Kozyrev; Gang Zheng; Chunfeng Zhu; Thomas J. Dougherty; Kevin M. Smith; Ravindra K. Pandey

doi:10.1016/0040-4039(96)01346-9

Syntheses of stable bacteriochlorophyll-a derivatives as potential photosensitizers for photodynamic therapy

Andrei N. Kozyrev
, Gang Zheng
, Chunfeng Zhu
, Thomas J. Dougherty
, Kevin M. Smith
, Ravindra K. Pandey

Institute for Lasers Photonics and Biophotonics

Roswell Park Cancer Institute
University of California at Davis

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

New methods for conversion of unstable bacteriochlorophyll-a present in Rb. sphaeroides into stable bacteriochlorins are presented. Cyclic imide derivatives from related cyclic isoimide or amide analogs are obtained by intramolecular base catalyzed cyclization. Most of the new bacteriochlorins have long wavelength absorptions in the range of 796-822 nm. In preliminary screening, the isoimide analogs have shown promising in vivo photosensitizing activity for the treatment of cancer by photodynamic therapy.

Original language	English
Pages (from-to)	6431-6434
Number of pages	4
Journal	Tetrahedron Letters
Volume	37
Issue number	36
DOIs	https://doi.org/10.1016/0040-4039(96)01346-9
State	Published - Sep 2 1996

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title = "Syntheses of stable bacteriochlorophyll-a derivatives as potential photosensitizers for photodynamic therapy",

abstract = "New methods for conversion of unstable bacteriochlorophyll-a present in Rb. sphaeroides into stable bacteriochlorins are presented. Cyclic imide derivatives from related cyclic isoimide or amide analogs are obtained by intramolecular base catalyzed cyclization. Most of the new bacteriochlorins have long wavelength absorptions in the range of 796-822 nm. In preliminary screening, the isoimide analogs have shown promising in vivo photosensitizing activity for the treatment of cancer by photodynamic therapy.",

author = "Kozyrev, \{Andrei N.\} and Gang Zheng and Chunfeng Zhu and Dougherty, \{Thomas J.\} and Smith, \{Kevin M.\} and Pandey, \{Ravindra K.\}",

year = "1996",

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doi = "10.1016/0040-4039(96)01346-9",

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T1 - Syntheses of stable bacteriochlorophyll-a derivatives as potential photosensitizers for photodynamic therapy

AU - Kozyrev, Andrei N.

AU - Zheng, Gang

AU - Zhu, Chunfeng

AU - Dougherty, Thomas J.

AU - Smith, Kevin M.

AU - Pandey, Ravindra K.

PY - 1996/9/2

Y1 - 1996/9/2

N2 - New methods for conversion of unstable bacteriochlorophyll-a present in Rb. sphaeroides into stable bacteriochlorins are presented. Cyclic imide derivatives from related cyclic isoimide or amide analogs are obtained by intramolecular base catalyzed cyclization. Most of the new bacteriochlorins have long wavelength absorptions in the range of 796-822 nm. In preliminary screening, the isoimide analogs have shown promising in vivo photosensitizing activity for the treatment of cancer by photodynamic therapy.

AB - New methods for conversion of unstable bacteriochlorophyll-a present in Rb. sphaeroides into stable bacteriochlorins are presented. Cyclic imide derivatives from related cyclic isoimide or amide analogs are obtained by intramolecular base catalyzed cyclization. Most of the new bacteriochlorins have long wavelength absorptions in the range of 796-822 nm. In preliminary screening, the isoimide analogs have shown promising in vivo photosensitizing activity for the treatment of cancer by photodynamic therapy.

UR - https://www.scopus.com/pages/publications/0030565603

U2 - 10.1016/0040-4039(96)01346-9

DO - 10.1016/0040-4039(96)01346-9

M3 - Article

AN - SCOPUS:0030565603

SN - 0040-4039

VL - 37

SP - 6431

EP - 6434

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 36

ER -

Syntheses of stable bacteriochlorophyll-a derivatives as potential photosensitizers for photodynamic therapy

Abstract

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