@inproceedings{ef3db6c45b8e49ebab16a04737a7e562,
title = "Syntheses of new porphyrin-type photosensitizers for photodynamic therapy",
abstract = "In the first part of this paper, syntheses of water-soluble photosensitizers for use in photodynamic therapy are described. Vinylporphyrins and vinylchlorins react with N.N- dimethylmethyleneammonium iodide (Eschenmoser's reagent) to give 2- (dimethylaminomethyl)vinyl derivatives which can be readily quaternized with methyl iodide to give highly water-soluble quaternary ammonium salts. Deuteroporphyrin-IX dimethyl ester undergoes direct substitution with dimethylaminomethyl at the nuclear 2- and 4-positions. The second part of this report describes the syntheses of bacteriochlorin analogues of natural chlorophyll derivatives; these are obtained by osmium tetraoxide oxidation of chlorins to give vic-dihydroxybacteriochlorins. Acid catalyzed pinacol-pinacolone rearrangements of a number of vic-dihydroxybacterochlorins to given ketobacteriochlorins are described, and the chemistry of the rearrangement is investigated. Biological studies of all sensitizers described will be reported elsewhere.",
author = "Smith, \{Kevin M.\} and Pandey, \{Ravindra K.\} and Shiau, \{Fuu Yau\} and Smith, \{Norman W.\} and Panos Iakovides and Dougherty, \{Thomas J.\}",
year = "1992",
language = "English",
isbn = "0819407917",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "Publ by Int Soc for Optical Engineering",
pages = "274--283",
booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",
note = "Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy ; Conference date: 20-01-1992 Through 21-01-1992",
}