Syntheses of cationic porphyrins and chlorins

Ravindra K. Pandey; Norman W. Smith; Fuu Yau Shiau; Thomas J. Dougherty; Kevin M. Smith

doi:10.1039/C39910001637

Syntheses of cationic porphyrins and chlorins

Ravindra K. Pandey
, Norman W. Smith
, Fuu Yau Shiau
, Thomas J. Dougherty
, Kevin M. Smith

Institute for Lasers Photonics and Biophotonics

University of California at Davis
Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Treatment of vinyl-chlorins 2,4,5 and -porphyrins 8 with N,N-dimethylmethyleneammonium iodide affords the corresponding vinyl-extended Mannich adducts 3,6,7,9; with deuteroporphyrin IX dimethyl ester 10 the product is the bis-Mannich base 11; quaternization of the products is readily accomplished with methyl iodide to afford a general method for synthesis of water-soluble cationic sensitizers for use in photodynamic therapy.

Original language	English
Pages (from-to)	1637-1638
Number of pages	2
Journal	Journal of the Chemical Society D: Chemical Communications
Issue number	22
DOIs	https://doi.org/10.1039/C39910001637
State	Published - 1991

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10.1039/C39910001637

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title = "Syntheses of cationic porphyrins and chlorins",

abstract = "Treatment of vinyl-chlorins 2,4,5 and -porphyrins 8 with N,N-dimethylmethyleneammonium iodide affords the corresponding vinyl-extended Mannich adducts 3,6,7,9; with deuteroporphyrin IX dimethyl ester 10 the product is the bis-Mannich base 11; quaternization of the products is readily accomplished with methyl iodide to afford a general method for synthesis of water-soluble cationic sensitizers for use in photodynamic therapy.",

author = "Pandey, \{Ravindra K.\} and Smith, \{Norman W.\} and Shiau, \{Fuu Yau\} and Dougherty, \{Thomas J.\} and Smith, \{Kevin M.\}",

year = "1991",

doi = "10.1039/C39910001637",

language = "English",

pages = "1637--1638",

journal = "Journal of the Chemical Society D: Chemical Communications",

issn = "0022-4936",

publisher = "Chemical Society",

number = "22",

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TY - JOUR

T1 - Syntheses of cationic porphyrins and chlorins

AU - Pandey, Ravindra K.

AU - Smith, Norman W.

AU - Shiau, Fuu Yau

AU - Dougherty, Thomas J.

AU - Smith, Kevin M.

PY - 1991

Y1 - 1991

N2 - Treatment of vinyl-chlorins 2,4,5 and -porphyrins 8 with N,N-dimethylmethyleneammonium iodide affords the corresponding vinyl-extended Mannich adducts 3,6,7,9; with deuteroporphyrin IX dimethyl ester 10 the product is the bis-Mannich base 11; quaternization of the products is readily accomplished with methyl iodide to afford a general method for synthesis of water-soluble cationic sensitizers for use in photodynamic therapy.

AB - Treatment of vinyl-chlorins 2,4,5 and -porphyrins 8 with N,N-dimethylmethyleneammonium iodide affords the corresponding vinyl-extended Mannich adducts 3,6,7,9; with deuteroporphyrin IX dimethyl ester 10 the product is the bis-Mannich base 11; quaternization of the products is readily accomplished with methyl iodide to afford a general method for synthesis of water-soluble cationic sensitizers for use in photodynamic therapy.

UR - https://www.scopus.com/pages/publications/37049084386

U2 - 10.1039/C39910001637

DO - 10.1039/C39910001637

M3 - Article

AN - SCOPUS:37049084386

SN - 0022-4936

SP - 1637

EP - 1638

JO - Journal of the Chemical Society D: Chemical Communications

JF - Journal of the Chemical Society D: Chemical Communications

IS - 22

ER -

Syntheses of cationic porphyrins and chlorins

Abstract

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