Surgical Construction of an in Vivo Carotid Siphon Model to Test Neurovascular Devices

Stavros A. Georganos; François Guilbert; Igor Salazkin; Guylaine Gévry; Jean Raymond; Ricardo A. Hanel; Elad I. Levy; L. Nelson Hopkins; Sean Cullen; Randall T. Higashida; Robert H. Rosenwasser; Jun B. Takahashi; Nobuo Hashimoto

doi:10.1227/01.NEU.0000119759.56437.F5

Surgical Construction of an in Vivo Carotid Siphon Model to Test Neurovascular Devices

Stavros A. Georganos
, François Guilbert
, Igor Salazkin
, Guylaine Gévry
, Jean Raymond
, Ricardo A. Hanel
, Elad I. Levy
, L. Nelson Hopkins
, Sean Cullen
, Randall T. Higashida
, Robert H. Rosenwasser
, Jun B. Takahashi
, Nobuo Hashimoto

Neurosurgery

Centre Hospitalier de L'Universite de Montreal

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

OBJECTIVE: We developed an animal model to evaluate vascular trauma induced by endovascular devices that are proposed for the treatment of cerebrovascular diseases. METHODS: The model was constructed in six domestic swine by elongating the common carotid artery using interpositional grafts. Balloon catheters (n = 3), stents (n = 2), and a snare were tested 9 to 13 days after surgery. Device performance was evaluated by angiography, macroscopic photography, and histopathological examination. RESULTS: Animals tolerated the surgical procedure well, and artificial siphons were thought to provide realistic conditions for device testing. Balloon catheters induced minimal trauma, whereas coronary stents caused severe spasm or thrombosis and extensive macroscopic changes. CONCLUSION: Construction of an in vivo siphon model is feasible and potentially useful for testing neurovascular devices.

Original language	English
Pages (from-to)	1239-1243
Number of pages	5
Journal	Neurosurgery
Volume	54
Issue number	5
DOIs	https://doi.org/10.1227/01.NEU.0000119759.56437.F5
State	Published - May 2004

Keywords

Animal model (pig)
Cerebrovascular disorders
Endovascular therapy
Intracranial vascular navigation

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Georganos, S. A., Guilbert, F., Salazkin, I., Gévry, G., Raymond, J., Hanel, R. A., Levy, E. I., Hopkins, L. N., Cullen, S., Higashida, R. T., Rosenwasser, R. H., Takahashi, J. B., & Hashimoto, N. (2004). Surgical Construction of an in Vivo Carotid Siphon Model to Test Neurovascular Devices. Neurosurgery, 54(5), 1239-1243. https://doi.org/10.1227/01.NEU.0000119759.56437.F5

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title = "Surgical Construction of an in Vivo Carotid Siphon Model to Test Neurovascular Devices",

abstract = "OBJECTIVE: We developed an animal model to evaluate vascular trauma induced by endovascular devices that are proposed for the treatment of cerebrovascular diseases. METHODS: The model was constructed in six domestic swine by elongating the common carotid artery using interpositional grafts. Balloon catheters (n = 3), stents (n = 2), and a snare were tested 9 to 13 days after surgery. Device performance was evaluated by angiography, macroscopic photography, and histopathological examination. RESULTS: Animals tolerated the surgical procedure well, and artificial siphons were thought to provide realistic conditions for device testing. Balloon catheters induced minimal trauma, whereas coronary stents caused severe spasm or thrombosis and extensive macroscopic changes. CONCLUSION: Construction of an in vivo siphon model is feasible and potentially useful for testing neurovascular devices.",

keywords = "Animal model (pig), Cerebrovascular disorders, Endovascular therapy, Intracranial vascular navigation",

author = "Georganos, \{Stavros A.\} and Fran{\c c}ois Guilbert and Igor Salazkin and Guylaine G{\'e}vry and Jean Raymond and Hanel, \{Ricardo A.\} and Levy, \{Elad I.\} and Hopkins, \{L. Nelson\} and Sean Cullen and Higashida, \{Randall T.\} and Rosenwasser, \{Robert H.\} and Takahashi, \{Jun B.\} and Nobuo Hashimoto",

year = "2004",

month = may,

doi = "10.1227/01.NEU.0000119759.56437.F5",

language = "English",

volume = "54",

pages = "1239--1243",

journal = "Neurosurgery",

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TY - JOUR

T1 - Surgical Construction of an in Vivo Carotid Siphon Model to Test Neurovascular Devices

AU - Georganos, Stavros A.

AU - Guilbert, François

AU - Salazkin, Igor

AU - Gévry, Guylaine

AU - Raymond, Jean

AU - Hanel, Ricardo A.

AU - Levy, Elad I.

AU - Hopkins, L. Nelson

AU - Cullen, Sean

AU - Higashida, Randall T.

AU - Rosenwasser, Robert H.

AU - Takahashi, Jun B.

AU - Hashimoto, Nobuo

PY - 2004/5

Y1 - 2004/5

N2 - OBJECTIVE: We developed an animal model to evaluate vascular trauma induced by endovascular devices that are proposed for the treatment of cerebrovascular diseases. METHODS: The model was constructed in six domestic swine by elongating the common carotid artery using interpositional grafts. Balloon catheters (n = 3), stents (n = 2), and a snare were tested 9 to 13 days after surgery. Device performance was evaluated by angiography, macroscopic photography, and histopathological examination. RESULTS: Animals tolerated the surgical procedure well, and artificial siphons were thought to provide realistic conditions for device testing. Balloon catheters induced minimal trauma, whereas coronary stents caused severe spasm or thrombosis and extensive macroscopic changes. CONCLUSION: Construction of an in vivo siphon model is feasible and potentially useful for testing neurovascular devices.

AB - OBJECTIVE: We developed an animal model to evaluate vascular trauma induced by endovascular devices that are proposed for the treatment of cerebrovascular diseases. METHODS: The model was constructed in six domestic swine by elongating the common carotid artery using interpositional grafts. Balloon catheters (n = 3), stents (n = 2), and a snare were tested 9 to 13 days after surgery. Device performance was evaluated by angiography, macroscopic photography, and histopathological examination. RESULTS: Animals tolerated the surgical procedure well, and artificial siphons were thought to provide realistic conditions for device testing. Balloon catheters induced minimal trauma, whereas coronary stents caused severe spasm or thrombosis and extensive macroscopic changes. CONCLUSION: Construction of an in vivo siphon model is feasible and potentially useful for testing neurovascular devices.

KW - Animal model (pig)

KW - Cerebrovascular disorders

KW - Endovascular therapy

KW - Intracranial vascular navigation

UR - https://www.scopus.com/pages/publications/2342570899

U2 - 10.1227/01.NEU.0000119759.56437.F5

DO - 10.1227/01.NEU.0000119759.56437.F5

M3 - Article

C2 - 15113480

AN - SCOPUS:2342570899

SN - 0148-396X

VL - 54

SP - 1239

EP - 1243

JO - Neurosurgery

JF - Neurosurgery

IS - 5

ER -

Surgical Construction of an in Vivo Carotid Siphon Model to Test Neurovascular Devices

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Keywords

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