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Surface-based reconstruction and diffusion MRI in the assessment of gray and white matter damage in multiple sclerosis

  • Matteo Caffini
  • , Niels Bergsland
  • , Marcella Laganà
  • , Eleonora Tavazzi
  • , Paola Tortorella
  • , Marco Rovaris
  • , Giuseppe Baselli
  • Polytechnic University of Milan
  • IRCCS Fondazione Don Carlo Gnocchi - Milano

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Despite advances in the application of nonconventional MRI techniques in furthering the understanding of multiple sclerosis pathogenic mechanisms, there are still many unanswered questions, such as the relationship between gray and white matter damage. We applied a combination of advanced surface-based reconstruction and diffusion tensor imaging techniques to address this issue. We found significant relationships between white matter tract integrity indices and corresponding cortical structures. Our results suggest a direct link between damage in white and gray matter and contribute to the notion of gray matter loss relating to clinical disability.

Original languageEnglish
Title of host publicationMedical Imaging 2014
Subtitle of host publicationImage Processing
PublisherSPIE
ISBN (Print)9780819498274
DOIs
StatePublished - 2014
EventMedical Imaging 2014: Image Processing - San Diego, CA, United States
Duration: Feb 16 2014Feb 18 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9034
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2014: Image Processing
Country/TerritoryUnited States
CitySan Diego, CA
Period02/16/1402/18/14

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