Suppression of water intake by immune complex formation in the hypothalamus. Implications for Systemic Lupus Erythematosus

S. A. Hoffman; D. W. Shucard; H. A. Brodie; C. Reifenrath; R. J. Harbeck

doi:10.1016/0165-5728(82)90007-8

Suppression of water intake by immune complex formation in the hypothalamus. Implications for Systemic Lupus Erythematosus

S. A. Hoffman
, D. W. Shucard
, H. A. Brodie
, C. Reifenrath
, R. J. Harbeck

Neurology

National Jewish Medical and Research Center

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Immune complex formation in the perifornical region of the hypothalamus resulted in depressed water consumption in rats, but did not consistently alter body temperature. The antibody with an unrelated antigen did not affect water consumption or body temperature. These results support the notion that immune complex reactions with the central nervous system can alter behavior.

Original language	English
Pages (from-to)	167-176
Number of pages	10
Journal	Journal of Neuroimmunology
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/0165-5728(82)90007-8
State	Published - Apr 1982

Keywords

Body temperature
Hypothalamus
Immune complex formation
Rat
Systemic lupus erythematosus
Water consumption

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10.1016/0165-5728(82)90007-8

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title = "Suppression of water intake by immune complex formation in the hypothalamus. Implications for Systemic Lupus Erythematosus",

abstract = "Immune complex formation in the perifornical region of the hypothalamus resulted in depressed water consumption in rats, but did not consistently alter body temperature. The antibody with an unrelated antigen did not affect water consumption or body temperature. These results support the notion that immune complex reactions with the central nervous system can alter behavior.",

keywords = "Body temperature, Hypothalamus, Immune complex formation, Rat, Systemic lupus erythematosus, Water consumption",

author = "Hoffman, \{S. A.\} and Shucard, \{D. W.\} and Brodie, \{H. A.\} and C. Reifenrath and Harbeck, \{R. J.\}",

year = "1982",

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AU - Hoffman, S. A.

AU - Shucard, D. W.

AU - Brodie, H. A.

AU - Reifenrath, C.

AU - Harbeck, R. J.

PY - 1982/4

Y1 - 1982/4

N2 - Immune complex formation in the perifornical region of the hypothalamus resulted in depressed water consumption in rats, but did not consistently alter body temperature. The antibody with an unrelated antigen did not affect water consumption or body temperature. These results support the notion that immune complex reactions with the central nervous system can alter behavior.

AB - Immune complex formation in the perifornical region of the hypothalamus resulted in depressed water consumption in rats, but did not consistently alter body temperature. The antibody with an unrelated antigen did not affect water consumption or body temperature. These results support the notion that immune complex reactions with the central nervous system can alter behavior.

KW - Body temperature

KW - Hypothalamus

KW - Immune complex formation

KW - Rat

KW - Systemic lupus erythematosus

KW - Water consumption

UR - https://www.scopus.com/pages/publications/0019992964

U2 - 10.1016/0165-5728(82)90007-8

DO - 10.1016/0165-5728(82)90007-8

M3 - Article

C2 - 7068844

AN - SCOPUS:0019992964

SN - 0165-5728

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EP - 176

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 2

ER -

Suppression of water intake by immune complex formation in the hypothalamus. Implications for Systemic Lupus Erythematosus

Abstract

Keywords

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