Substrate specificity for catalysis of phosphodiester cleavage by a dinuclear Zn(II) complex

Meng Yin Yang; John P. Richard; Janet R. Morrow

doi:10.1039/b308644e

Substrate specificity for catalysis of phosphodiester cleavage by a dinuclear Zn(II) complex

Chemistry

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

The 2.4 kcal mol⁻¹ greater stabilization of the transition state for cleavage of the minimal substrate HpPNP compared to the nucleoside substrate UpPNP by the efficient dinuclear metal ion catalyst Zn₂(L₂O) provides evidence that access to the cationic core of Zn₂(L₂O) is sterically blocked for the bulkier nucleoside substrates, a flaw that will need to be dealt with in later generations of metal ion catalysts of RNA cleavage.

Original language	English
Pages (from-to)	2832-2833
Number of pages	2
Journal	Chemical Communications
Volume	3
Issue number	22
DOIs	https://doi.org/10.1039/b308644e
State	Published - 2003

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title = "Substrate specificity for catalysis of phosphodiester cleavage by a dinuclear Zn(II) complex",

abstract = "The 2.4 kcal mol−1 greater stabilization of the transition state for cleavage of the minimal substrate HpPNP compared to the nucleoside substrate UpPNP by the efficient dinuclear metal ion catalyst Zn2(L2O) provides evidence that access to the cationic core of Zn2(L2O) is sterically blocked for the bulkier nucleoside substrates, a flaw that will need to be dealt with in later generations of metal ion catalysts of RNA cleavage.",

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journal = "Chemical Communications",

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AU - Yang, Meng Yin

AU - Richard, John P.

AU - Morrow, Janet R.

PY - 2003

Y1 - 2003

N2 - The 2.4 kcal mol−1 greater stabilization of the transition state for cleavage of the minimal substrate HpPNP compared to the nucleoside substrate UpPNP by the efficient dinuclear metal ion catalyst Zn2(L2O) provides evidence that access to the cationic core of Zn2(L2O) is sterically blocked for the bulkier nucleoside substrates, a flaw that will need to be dealt with in later generations of metal ion catalysts of RNA cleavage.

AB - The 2.4 kcal mol−1 greater stabilization of the transition state for cleavage of the minimal substrate HpPNP compared to the nucleoside substrate UpPNP by the efficient dinuclear metal ion catalyst Zn2(L2O) provides evidence that access to the cationic core of Zn2(L2O) is sterically blocked for the bulkier nucleoside substrates, a flaw that will need to be dealt with in later generations of metal ion catalysts of RNA cleavage.

UR - https://www.scopus.com/pages/publications/0344099382

U2 - 10.1039/b308644e

DO - 10.1039/b308644e

M3 - Article

C2 - 14651127

AN - SCOPUS:0344099382

SN - 1359-7345

VL - 3

SP - 2832

EP - 2833

JO - Chemical Communications

JF - Chemical Communications

IS - 22

ER -

Substrate specificity for catalysis of phosphodiester cleavage by a dinuclear Zn(II) complex

Abstract

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