Substituted 2-(2-Hydroxyphenyl)benzimidazoles as Potential Agents for the Control of Periodontal Diseases

Robert A. Coburn; Michael T. Clark; Richard T. Evans; Robert J. Genco

doi:10.1021/jm00384a035

Substituted 2-(2-Hydroxyphenyl)benzimidazoles as Potential Agents for the Control of Periodontal Diseases

Robert A. Coburn
, Michael T. Clark
, Richard T. Evans
, Robert J. Genco

Chemistry

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

A series of 16 substituted 2-(2-hydroxphenyl)benzimidazoles was synthesized and evaluated in vitro for antibacterial activity against bacteria associated with periodontal diseases. Several compounds demonstrated a high level of activity, in tube dilution assay, against Actinomycetes viscosus and Bacteriodes gingivalis. These results indicate that several of these compounds may serve as topical antibacterial agents for the control of acute marginal inflammatory gingivitis and periodontitis.

Original language	English
Pages (from-to)	205-208
Number of pages	4
Journal	Journal of Medicinal Chemistry
Volume	30
Issue number	1
DOIs	https://doi.org/10.1021/jm00384a035
State	Published - Jan 1 1987

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10.1021/jm00384a035

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title = "Substituted 2-(2-Hydroxyphenyl)benzimidazoles as Potential Agents for the Control of Periodontal Diseases",

abstract = "A series of 16 substituted 2-(2-hydroxphenyl)benzimidazoles was synthesized and evaluated in vitro for antibacterial activity against bacteria associated with periodontal diseases. Several compounds demonstrated a high level of activity, in tube dilution assay, against Actinomycetes viscosus and Bacteriodes gingivalis. These results indicate that several of these compounds may serve as topical antibacterial agents for the control of acute marginal inflammatory gingivitis and periodontitis.",

author = "Coburn, \{Robert A.\} and Clark, \{Michael T.\} and Evans, \{Richard T.\} and Genco, \{Robert J.\}",

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AU - Coburn, Robert A.

AU - Clark, Michael T.

AU - Evans, Richard T.

AU - Genco, Robert J.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - A series of 16 substituted 2-(2-hydroxphenyl)benzimidazoles was synthesized and evaluated in vitro for antibacterial activity against bacteria associated with periodontal diseases. Several compounds demonstrated a high level of activity, in tube dilution assay, against Actinomycetes viscosus and Bacteriodes gingivalis. These results indicate that several of these compounds may serve as topical antibacterial agents for the control of acute marginal inflammatory gingivitis and periodontitis.

AB - A series of 16 substituted 2-(2-hydroxphenyl)benzimidazoles was synthesized and evaluated in vitro for antibacterial activity against bacteria associated with periodontal diseases. Several compounds demonstrated a high level of activity, in tube dilution assay, against Actinomycetes viscosus and Bacteriodes gingivalis. These results indicate that several of these compounds may serve as topical antibacterial agents for the control of acute marginal inflammatory gingivitis and periodontitis.

UR - https://www.scopus.com/pages/publications/0023085041

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DO - 10.1021/jm00384a035

M3 - Article

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JO - Journal of Medicinal Chemistry

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ER -

Substituted 2-(2-Hydroxyphenyl)benzimidazoles as Potential Agents for the Control of Periodontal Diseases

Abstract

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