Structure/activity relationships among photosensitizers related to pheophorbides and bacteriopheophorbides

Ravindra K. Pandey; Fuu Yau Shiau; Adam B. Sumlin; Thomas J. Dougherty; Kevin M. Smith

doi:10.1016/S0960-894X(00)80176-6

Structure/activity relationships among photosensitizers related to pheophorbides and bacteriopheophorbides

Ravindra K. Pandey
, Fuu Yau Shiau
, Adam B. Sumlin
, Thomas J. Dougherty
, Kevin M. Smith

Institute for Lasers Photonics and Biophotonics

University of California at Davis
Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

A series of long wavelength absorbing photosensitizers related to pheophorbide-a, pyropheophorbide-a, bacteriopheophorbide-a and chlorin-e₆ were synthesized and evaluated for their comparative in vivo tumorcidal activity and skin phototoxicity vis-a-vis Photofrin®. Structure/function relationships are discussed. All new photosensitizers were found to have high production of ¹O₂ and reduced skin phototoxicity compared to Photofrin®.

Original language	English
Pages (from-to)	491-496
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	2
Issue number	5
DOIs	https://doi.org/10.1016/S0960-894X(00)80176-6
State	Published - 1992

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title = "Structure/activity relationships among photosensitizers related to pheophorbides and bacteriopheophorbides",

abstract = "A series of long wavelength absorbing photosensitizers related to pheophorbide-a, pyropheophorbide-a, bacteriopheophorbide-a and chlorin-e6 were synthesized and evaluated for their comparative in vivo tumorcidal activity and skin phototoxicity vis-a-vis Photofrin{\textregistered}. Structure/function relationships are discussed. All new photosensitizers were found to have high production of 1O2 and reduced skin phototoxicity compared to Photofrin{\textregistered}.",

author = "Pandey, \{Ravindra K.\} and Shiau, \{Fuu Yau\} and Sumlin, \{Adam B.\} and Dougherty, \{Thomas J.\} and Smith, \{Kevin M.\}",

year = "1992",

doi = "10.1016/S0960-894X(00)80176-6",

language = "English",

volume = "2",

pages = "491--496",

journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Structure/activity relationships among photosensitizers related to pheophorbides and bacteriopheophorbides

AU - Pandey, Ravindra K.

AU - Shiau, Fuu Yau

AU - Sumlin, Adam B.

AU - Dougherty, Thomas J.

AU - Smith, Kevin M.

PY - 1992

Y1 - 1992

N2 - A series of long wavelength absorbing photosensitizers related to pheophorbide-a, pyropheophorbide-a, bacteriopheophorbide-a and chlorin-e6 were synthesized and evaluated for their comparative in vivo tumorcidal activity and skin phototoxicity vis-a-vis Photofrin®. Structure/function relationships are discussed. All new photosensitizers were found to have high production of 1O2 and reduced skin phototoxicity compared to Photofrin®.

AB - A series of long wavelength absorbing photosensitizers related to pheophorbide-a, pyropheophorbide-a, bacteriopheophorbide-a and chlorin-e6 were synthesized and evaluated for their comparative in vivo tumorcidal activity and skin phototoxicity vis-a-vis Photofrin®. Structure/function relationships are discussed. All new photosensitizers were found to have high production of 1O2 and reduced skin phototoxicity compared to Photofrin®.

UR - https://www.scopus.com/pages/publications/0026737238

U2 - 10.1016/S0960-894X(00)80176-6

DO - 10.1016/S0960-894X(00)80176-6

M3 - Article

AN - SCOPUS:0026737238

SN - 0960-894X

VL - 2

SP - 491

EP - 496

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 5

ER -

Structure/activity relationships among photosensitizers related to pheophorbides and bacteriopheophorbides

Abstract

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