Structure, synthesis, and antitumor activity of the hydrolysis product of the antitumor agent carmethizole

Wayne K. Anderson; D. Michael Houston; Mark A. Jarosinski; Frederick R. Kinder; Rao N. Kode; Patrick Van Roey; Jeffrey M. Salerno

doi:10.1002/ddr.430300306

Structure, synthesis, and antitumor activity of the hydrolysis product of the antitumor agent carmethizole

Wayne K. Anderson
, D. Michael Houston
, Mark A. Jarosinski
, Frederick R. Kinder
, Rao N. Kode
, Patrick Van Roey
, Jeffrey M. Salerno

Pharmaceutical Sciences

SUNY Buffalo
Hauptman-Woodward Medical Research Institute, Inc.

Research output: Contribution to journal › Article › peer-review

Abstract

The two isomeric monocarbamates, 2b and 2c, related to the antitumor drug carmethizole (1) were synthesized and the structure of the carmethizole hydrolysis product, 2b, was established by X‐ray crystallography. The chemical reactivity, toxicity, and antitumor activity of the two monocarbamates, 2b and 2c, were compared with 1. © 1993 wiley‐Liss, Inc.

Original language	English
Pages (from-to)	143-146
Number of pages	4
Journal	Drug Development Research
Volume	30
Issue number	3
DOIs	https://doi.org/10.1002/ddr.430300306
State	Published - Nov 1993

Keywords

anticancer
carmethizole
hydrolysis
toxicity

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10.1002/ddr.430300306

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title = "Structure, synthesis, and antitumor activity of the hydrolysis product of the antitumor agent carmethizole",

abstract = "The two isomeric monocarbamates, 2b and 2c, related to the antitumor drug carmethizole (1) were synthesized and the structure of the carmethizole hydrolysis product, 2b, was established by X‐ray crystallography. The chemical reactivity, toxicity, and antitumor activity of the two monocarbamates, 2b and 2c, were compared with 1. {\textcopyright} 1993 wiley‐Liss, Inc.",

keywords = "anticancer, carmethizole, hydrolysis, toxicity",

author = "Anderson, \{Wayne K.\} and Houston, \{D. Michael\} and Jarosinski, \{Mark A.\} and Kinder, \{Frederick R.\} and Kode, \{Rao N.\} and \{Van Roey\}, Patrick and Salerno, \{Jeffrey M.\}",

year = "1993",

month = nov,

doi = "10.1002/ddr.430300306",

language = "English",

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TY - JOUR

T1 - Structure, synthesis, and antitumor activity of the hydrolysis product of the antitumor agent carmethizole

AU - Anderson, Wayne K.

AU - Houston, D. Michael

AU - Jarosinski, Mark A.

AU - Kinder, Frederick R.

AU - Kode, Rao N.

AU - Van Roey, Patrick

AU - Salerno, Jeffrey M.

PY - 1993/11

Y1 - 1993/11

N2 - The two isomeric monocarbamates, 2b and 2c, related to the antitumor drug carmethizole (1) were synthesized and the structure of the carmethizole hydrolysis product, 2b, was established by X‐ray crystallography. The chemical reactivity, toxicity, and antitumor activity of the two monocarbamates, 2b and 2c, were compared with 1. © 1993 wiley‐Liss, Inc.

AB - The two isomeric monocarbamates, 2b and 2c, related to the antitumor drug carmethizole (1) were synthesized and the structure of the carmethizole hydrolysis product, 2b, was established by X‐ray crystallography. The chemical reactivity, toxicity, and antitumor activity of the two monocarbamates, 2b and 2c, were compared with 1. © 1993 wiley‐Liss, Inc.

KW - anticancer

KW - carmethizole

KW - hydrolysis

KW - toxicity

UR - https://www.scopus.com/pages/publications/0027768956

U2 - 10.1002/ddr.430300306

DO - 10.1002/ddr.430300306

M3 - Article

AN - SCOPUS:0027768956

SN - 0272-4391

VL - 30

SP - 143

EP - 146

JO - Drug Development Research

JF - Drug Development Research

IS - 3

ER -

Structure, synthesis, and antitumor activity of the hydrolysis product of the antitumor agent carmethizole

Abstract

Keywords

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