Structure of ribose 5-phosphate isomerase from Plasmodium falciparum

Margaret A. Holmes; Frederick S. Buckner; Wesley C. Van Voorhis; Christophe L.M.J. Verlinde; Christopher Mehlin; Erica Boni; George DeTitta; Joseph Luft; Angela Lauricella; Lori Anderson; Oleksandr Kalyuzhniy; Frank Zucker; Lori W. Schoenfeld; Thomas N. Earnest; Wim G.J. Hol; Ethan A. Merritt

doi:10.1107/S1744309106010876

Structure of ribose 5-phosphate isomerase from Plasmodium falciparum

Margaret A. Holmes
, Frederick S. Buckner
, Wesley C. Van Voorhis
, Christophe L.M.J. Verlinde
, Christopher Mehlin
, Erica Boni
, George DeTitta
, Joseph Luft
, Angela Lauricella
, Lori Anderson
, Oleksandr Kalyuzhniy
, Frank Zucker
, Lori W. Schoenfeld
, Thomas N. Earnest
, Wim G.J. Hol
, Ethan A. Merritt

Department of Structural Biology

University of Washington
Hauptman-Woodward Medical Research Institute, Inc.
Lawrence Berkeley National Laboratory

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The structure of ribose 5-phosphate isomerase from Plasmodium falciparum, PFE0730c, has been determined by molecular replacement at 2.09 Å resolution. The enzyme, which catalyzes the isomerization reaction that interconverts ribose 5-phosphate and ribulose 5-phosphate, is a member of the pentose phosphate pathway. The P. falciparum enzyme belongs to the ribose 5-phosphate isomerase A family, Pfam family PF06562 (DUF1124), and is structurally similar to other members of the family.

Original language	English
Pages (from-to)	427-431
Number of pages	5
Journal	Acta Crystallographica Section F: Structural Biology and Crystallization Communications
Volume	62
Issue number	5
DOIs	https://doi.org/10.1107/S1744309106010876
State	Published - May 2006

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Holmes, M. A., Buckner, F. S., Van Voorhis, W. C., Verlinde, C. L. M. J., Mehlin, C., Boni, E., DeTitta, G., Luft, J., Lauricella, A., Anderson, L., Kalyuzhniy, O., Zucker, F., Schoenfeld, L. W., Earnest, T. N., Hol, W. G. J., & Merritt, E. A. (2006). Structure of ribose 5-phosphate isomerase from Plasmodium falciparum. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 62(5), 427-431. https://doi.org/10.1107/S1744309106010876

@article{86d403a52ca64f0aa0a48a6e00f5f8f5,

title = "Structure of ribose 5-phosphate isomerase from Plasmodium falciparum",

abstract = "The structure of ribose 5-phosphate isomerase from Plasmodium falciparum, PFE0730c, has been determined by molecular replacement at 2.09 {\AA} resolution. The enzyme, which catalyzes the isomerization reaction that interconverts ribose 5-phosphate and ribulose 5-phosphate, is a member of the pentose phosphate pathway. The P. falciparum enzyme belongs to the ribose 5-phosphate isomerase A family, Pfam family PF06562 (DUF1124), and is structurally similar to other members of the family.",

author = "Holmes, \{Margaret A.\} and Buckner, \{Frederick S.\} and \{Van Voorhis\}, \{Wesley C.\} and Verlinde, \{Christophe L.M.J.\} and Christopher Mehlin and Erica Boni and George DeTitta and Joseph Luft and Angela Lauricella and Lori Anderson and Oleksandr Kalyuzhniy and Frank Zucker and Schoenfeld, \{Lori W.\} and Earnest, \{Thomas N.\} and Hol, \{Wim G.J.\} and Merritt, \{Ethan A.\}",

year = "2006",

month = may,

doi = "10.1107/S1744309106010876",

language = "English",

volume = "62",

pages = "427--431",

journal = "Acta Crystallographica Section F: Structural Biology and Crystallization Communications",

issn = "1744-3091",

publisher = "International Union of Crystallography",

number = "5",

}

Holmes, MA, Buckner, FS, Van Voorhis, WC, Verlinde, CLMJ, Mehlin, C, Boni, E, DeTitta, G, Luft, J, Lauricella, A, Anderson, L, Kalyuzhniy, O, Zucker, F, Schoenfeld, LW, Earnest, TN, Hol, WGJ & Merritt, EA 2006, 'Structure of ribose 5-phosphate isomerase from Plasmodium falciparum', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, vol. 62, no. 5, pp. 427-431. https://doi.org/10.1107/S1744309106010876

TY - JOUR

T1 - Structure of ribose 5-phosphate isomerase from Plasmodium falciparum

AU - Holmes, Margaret A.

AU - Buckner, Frederick S.

AU - Van Voorhis, Wesley C.

AU - Verlinde, Christophe L.M.J.

AU - Mehlin, Christopher

AU - Boni, Erica

AU - DeTitta, George

AU - Luft, Joseph

AU - Lauricella, Angela

AU - Anderson, Lori

AU - Kalyuzhniy, Oleksandr

AU - Zucker, Frank

AU - Schoenfeld, Lori W.

AU - Earnest, Thomas N.

AU - Hol, Wim G.J.

AU - Merritt, Ethan A.

PY - 2006/5

Y1 - 2006/5

N2 - The structure of ribose 5-phosphate isomerase from Plasmodium falciparum, PFE0730c, has been determined by molecular replacement at 2.09 Å resolution. The enzyme, which catalyzes the isomerization reaction that interconverts ribose 5-phosphate and ribulose 5-phosphate, is a member of the pentose phosphate pathway. The P. falciparum enzyme belongs to the ribose 5-phosphate isomerase A family, Pfam family PF06562 (DUF1124), and is structurally similar to other members of the family.

AB - The structure of ribose 5-phosphate isomerase from Plasmodium falciparum, PFE0730c, has been determined by molecular replacement at 2.09 Å resolution. The enzyme, which catalyzes the isomerization reaction that interconverts ribose 5-phosphate and ribulose 5-phosphate, is a member of the pentose phosphate pathway. The P. falciparum enzyme belongs to the ribose 5-phosphate isomerase A family, Pfam family PF06562 (DUF1124), and is structurally similar to other members of the family.

UR - https://www.scopus.com/pages/publications/33646827993

U2 - 10.1107/S1744309106010876

DO - 10.1107/S1744309106010876

M3 - Article

C2 - 16682767

AN - SCOPUS:33646827993

SN - 1744-3091

VL - 62

SP - 427

EP - 431

JO - Acta Crystallographica Section F: Structural Biology and Crystallization Communications

JF - Acta Crystallographica Section F: Structural Biology and Crystallization Communications

IS - 5

ER -

Structure of ribose 5-phosphate isomerase from Plasmodium falciparum

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