Structure of progesterone hydroquinone monohydrate (1:1:1), C₂₁H₃₀O₂·C₆H₆O₂·H₂O

The crystal structure of progesterone hydroquinone monohydrate was determined by means of X-ray diffraction methods:M_r=442.6, orthorhombic, P2₁2₁2₁, a=14.680(2), b=22.725(3), c=7.334(1) Å, V_a=2446.6(6) ų, Z=4, D_x=1.190 M gm^-3, Mo Kα radiation {Mathematical expression}, μ(Mo Kα)=0.75 cm^-1, F(000)=948. The structure was solved using Multan;R=0.059, R_w=0.059 for 2736 reflections. This progesterone molecule has the most flattened A ring, relative to the rest of the skeleton, of all progesterone molecules studied so far. Steroid, hydroquinone, and water molecules form, by means of hydrogen bonds, two parallel chains connected with each other by hydrogen bonds.