Structural features of piperazinyl-linked ciprofloxacin dimers required for activity against drug-resistant strains of Staphylococcus aureus

Robert J. Kerns; Michael J. Rybak; Glenn W. Kaatz; Flamur Vaka; Raymond Cha; Richard G. Grucz; Veena U. Diwadkar

doi:10.1016/S0960-894X(03)00376-7

Structural features of piperazinyl-linked ciprofloxacin dimers required for activity against drug-resistant strains of Staphylococcus aureus

Robert J. Kerns
, Michael J. Rybak
, Glenn W. Kaatz
, Flamur Vaka
, Raymond Cha
, Richard G. Grucz
, Veena U. Diwadkar

Pharmacy

University of Iowa
Wayne State University

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Abstract

We previously demonstrated that piperazinyl-linked fluoroquinolone dimers possess potent antibacterial activity against drug-resistant strains of Staphylococcus aureus. In this study, we report the preparation and evaluation of a series of incomplete dimers toward ascertaining structural features of piperazinyl-linked ciprofloxacin dimers that render these agents refractory to fluoroquinolone-resistance mechanisms in Staphylococcus aureus.

Original language	English
Pages (from-to)	2109-2112
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	13
DOIs	https://doi.org/10.1016/S0960-894X(03)00376-7
State	Published - Jul 7 2003

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title = "Structural features of piperazinyl-linked ciprofloxacin dimers required for activity against drug-resistant strains of Staphylococcus aureus",

abstract = "We previously demonstrated that piperazinyl-linked fluoroquinolone dimers possess potent antibacterial activity against drug-resistant strains of Staphylococcus aureus. In this study, we report the preparation and evaluation of a series of incomplete dimers toward ascertaining structural features of piperazinyl-linked ciprofloxacin dimers that render these agents refractory to fluoroquinolone-resistance mechanisms in Staphylococcus aureus.",

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AU - Kerns, Robert J.

AU - Rybak, Michael J.

AU - Kaatz, Glenn W.

AU - Vaka, Flamur

AU - Cha, Raymond

AU - Grucz, Richard G.

AU - Diwadkar, Veena U.

PY - 2003/7/7

Y1 - 2003/7/7

N2 - We previously demonstrated that piperazinyl-linked fluoroquinolone dimers possess potent antibacterial activity against drug-resistant strains of Staphylococcus aureus. In this study, we report the preparation and evaluation of a series of incomplete dimers toward ascertaining structural features of piperazinyl-linked ciprofloxacin dimers that render these agents refractory to fluoroquinolone-resistance mechanisms in Staphylococcus aureus.

AB - We previously demonstrated that piperazinyl-linked fluoroquinolone dimers possess potent antibacterial activity against drug-resistant strains of Staphylococcus aureus. In this study, we report the preparation and evaluation of a series of incomplete dimers toward ascertaining structural features of piperazinyl-linked ciprofloxacin dimers that render these agents refractory to fluoroquinolone-resistance mechanisms in Staphylococcus aureus.

UR - https://www.scopus.com/pages/publications/0037534121

U2 - 10.1016/S0960-894X(03)00376-7

DO - 10.1016/S0960-894X(03)00376-7

M3 - Article

C2 - 12798315

AN - SCOPUS:0037534121

SN - 0960-894X

VL - 13

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 13

ER -

Structural features of piperazinyl-linked ciprofloxacin dimers required for activity against drug-resistant strains of Staphylococcus aureus

Abstract

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