As a response to growing needs of airlifting capability, an ultra heavy lifting Blended Wing Body military cargo transport is proposed. The BWB configurations holds a major technical challenge in its center body structure resisting both cabin pressurization and wing bending loads. A Columned Multi Bubble Fuselage (CMBF) is introduced and analyzed for the wide and continuous cabin area. It replaces inter-cabin walls of the existing configuration with a series of columns to prevent the mission interruptions. In the initial development analysis, it was found that the CMBF has a significant weight advantages. The paper presents the preliminary structural design and its analysis results.