Striatal 3-methoxytyramine as an index of dopamine release: Effects of electrical stimulation

P. L. Wood; N. P.V. Nair; M. Bozarth

doi:10.1016/0304-3940(82)90309-3

Striatal 3-methoxytyramine as an index of dopamine release: Effects of electrical stimulation

P. L. Wood
, N. P.V. Nair
, M. Bozarth

Psychology

Douglas Mental Health University Institute

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Electrical stimulation of the substantia nigra elicited frequency-dependent increases in striatal 3-methoxytramine (3-MT). Subsequently, successive increases in dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were measured. Inhibition of nigrostriatal cell firing with HA-966 resulted in decreased striatal 3-MT, but in this case elevated DOPAC and HVA were also observed. These data indicate that 3-MT is a reliable index of dopamine (DA) release but that concurrent measurements of DOPAC, HVA and DA provide the most reliable interpretation of drug effects on dopaminergic function.

Original language	English
Pages (from-to)	291-294
Number of pages	4
Journal	Neuroscience Letters
Volume	32
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(82)90309-3
State	Published - Oct 23 1982

Keywords

electrical stimulation
HA-966
striatal 3-methoxytyramine

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10.1016/0304-3940(82)90309-3

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title = "Striatal 3-methoxytyramine as an index of dopamine release: Effects of electrical stimulation",

abstract = "Electrical stimulation of the substantia nigra elicited frequency-dependent increases in striatal 3-methoxytramine (3-MT). Subsequently, successive increases in dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were measured. Inhibition of nigrostriatal cell firing with HA-966 resulted in decreased striatal 3-MT, but in this case elevated DOPAC and HVA were also observed. These data indicate that 3-MT is a reliable index of dopamine (DA) release but that concurrent measurements of DOPAC, HVA and DA provide the most reliable interpretation of drug effects on dopaminergic function.",

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T2 - Effects of electrical stimulation

AU - Wood, P. L.

AU - Nair, N. P.V.

AU - Bozarth, M.

PY - 1982/10/23

Y1 - 1982/10/23

N2 - Electrical stimulation of the substantia nigra elicited frequency-dependent increases in striatal 3-methoxytramine (3-MT). Subsequently, successive increases in dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were measured. Inhibition of nigrostriatal cell firing with HA-966 resulted in decreased striatal 3-MT, but in this case elevated DOPAC and HVA were also observed. These data indicate that 3-MT is a reliable index of dopamine (DA) release but that concurrent measurements of DOPAC, HVA and DA provide the most reliable interpretation of drug effects on dopaminergic function.

AB - Electrical stimulation of the substantia nigra elicited frequency-dependent increases in striatal 3-methoxytramine (3-MT). Subsequently, successive increases in dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were measured. Inhibition of nigrostriatal cell firing with HA-966 resulted in decreased striatal 3-MT, but in this case elevated DOPAC and HVA were also observed. These data indicate that 3-MT is a reliable index of dopamine (DA) release but that concurrent measurements of DOPAC, HVA and DA provide the most reliable interpretation of drug effects on dopaminergic function.

KW - electrical stimulation

KW - HA-966

KW - striatal 3-methoxytyramine

UR - https://www.scopus.com/pages/publications/0020407260

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SN - 0304-3940

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EP - 294

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Striatal 3-methoxytyramine as an index of dopamine release: Effects of electrical stimulation

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Keywords

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