Storable palladacycles for selective functionalization of alkyne-containing proteins

Gang Cheng; Reyna K.V. Lim; Nan Li; Qing Lin

doi:10.1039/c3cc43479f

Storable palladacycles for selective functionalization of alkyne-containing proteins

Gang Cheng
, Reyna K.V. Lim
, Nan Li
, Qing Lin

Chemistry

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

We report the facile preparation of palladacycles as storable arylpalladium(II) reagents from acetanilides via cyclopalladation. The palladacycles exhibit good stability in PBS buffer and are capable of functionalizing a metabolically encoded HPG-containing protein, thus providing a new type of biocompatible organometallic reagent for selectively functionalizing the alkyne-encoded proteins.

Original language	English
Pages (from-to)	6809-6811
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	60
DOIs	https://doi.org/10.1039/c3cc43479f
State	Published - Jul 2 2013

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title = "Storable palladacycles for selective functionalization of alkyne-containing proteins",

abstract = "We report the facile preparation of palladacycles as storable arylpalladium(II) reagents from acetanilides via cyclopalladation. The palladacycles exhibit good stability in PBS buffer and are capable of functionalizing a metabolically encoded HPG-containing protein, thus providing a new type of biocompatible organometallic reagent for selectively functionalizing the alkyne-encoded proteins.",

author = "Gang Cheng and Lim, \{Reyna K.V.\} and Nan Li and Qing Lin",

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AU - Cheng, Gang

AU - Lim, Reyna K.V.

AU - Li, Nan

AU - Lin, Qing

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Y1 - 2013/7/2

N2 - We report the facile preparation of palladacycles as storable arylpalladium(II) reagents from acetanilides via cyclopalladation. The palladacycles exhibit good stability in PBS buffer and are capable of functionalizing a metabolically encoded HPG-containing protein, thus providing a new type of biocompatible organometallic reagent for selectively functionalizing the alkyne-encoded proteins.

AB - We report the facile preparation of palladacycles as storable arylpalladium(II) reagents from acetanilides via cyclopalladation. The palladacycles exhibit good stability in PBS buffer and are capable of functionalizing a metabolically encoded HPG-containing protein, thus providing a new type of biocompatible organometallic reagent for selectively functionalizing the alkyne-encoded proteins.

UR - https://www.scopus.com/pages/publications/84879968280

U2 - 10.1039/c3cc43479f

DO - 10.1039/c3cc43479f

M3 - Article

C2 - 23778852

AN - SCOPUS:84879968280

SN - 1359-7345

VL - 49

SP - 6809

EP - 6811

JO - Chemical Communications

JF - Chemical Communications

IS - 60

ER -

Storable palladacycles for selective functionalization of alkyne-containing proteins

Abstract

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