Steroid molecular structure and recognition by enzymes, receptors and binding proteins

W. L. Duax; M. Fronckowiak; J. F. Griffin; J. Punzi

Steroid molecular structure and recognition by enzymes, receptors and binding proteins

W. L. Duax
, M. Fronckowiak
, J. F. Griffin
, J. Punzi

Department of Structural Biology

Hauptman-Woodward Medical Research Institute, Inc.

Research output: Contribution to journal › Conference article › peer-review

Abstract

The mechanism of action of estrogen synthetase is being investigated using a combination of biochemical and biophysical techniques. On the basis of the analysis of crystallographically observed conformations of hundreds of steroid structures, an A-ring binding/D-ring acting model for the action of estrogens, progestins and corticoids has been proposed. In this model the steroid A-ring plays a primary role in initiating and maintaining hormone receptor binding and the stereochemistry and substituents present in the D-ring of the hormone control agonist or antagonist response.

Original language	English
Pages (from-to)	94-95
Number of pages	2
Journal	Journal of Molecular Graphics
Volume	7
Issue number	2
State	Published - Jun 1989
Event	Conference Papers from the Symposium on Molecular Recognition: Its Role in Chemistry and Biochemistry - Sopron, Hung, USA Duration: Aug 24 1988 → Aug 27 1988

Cite this

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title = "Steroid molecular structure and recognition by enzymes, receptors and binding proteins",

abstract = "The mechanism of action of estrogen synthetase is being investigated using a combination of biochemical and biophysical techniques. On the basis of the analysis of crystallographically observed conformations of hundreds of steroid structures, an A-ring binding/D-ring acting model for the action of estrogens, progestins and corticoids has been proposed. In this model the steroid A-ring plays a primary role in initiating and maintaining hormone receptor binding and the stereochemistry and substituents present in the D-ring of the hormone control agonist or antagonist response.",

author = "Duax, \{W. L.\} and M. Fronckowiak and Griffin, \{J. F.\} and J. Punzi",

year = "1989",

month = jun,

language = "English",

volume = "7",

pages = "94--95",

journal = "Journal of Molecular Graphics",

issn = "0263-7855",

publisher = "Elsevier B.V.",

number = "2",

note = "Conference Papers from the Symposium on Molecular Recognition: Its Role in Chemistry and Biochemistry ; Conference date: 24-08-1988 Through 27-08-1988",

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TY - JOUR

T1 - Steroid molecular structure and recognition by enzymes, receptors and binding proteins

AU - Duax, W. L.

AU - Fronckowiak, M.

AU - Griffin, J. F.

AU - Punzi, J.

PY - 1989/6

Y1 - 1989/6

N2 - The mechanism of action of estrogen synthetase is being investigated using a combination of biochemical and biophysical techniques. On the basis of the analysis of crystallographically observed conformations of hundreds of steroid structures, an A-ring binding/D-ring acting model for the action of estrogens, progestins and corticoids has been proposed. In this model the steroid A-ring plays a primary role in initiating and maintaining hormone receptor binding and the stereochemistry and substituents present in the D-ring of the hormone control agonist or antagonist response.

AB - The mechanism of action of estrogen synthetase is being investigated using a combination of biochemical and biophysical techniques. On the basis of the analysis of crystallographically observed conformations of hundreds of steroid structures, an A-ring binding/D-ring acting model for the action of estrogens, progestins and corticoids has been proposed. In this model the steroid A-ring plays a primary role in initiating and maintaining hormone receptor binding and the stereochemistry and substituents present in the D-ring of the hormone control agonist or antagonist response.

UR - https://www.scopus.com/pages/publications/0024684696

M3 - Conference article

AN - SCOPUS:0024684696

SN - 0263-7855

VL - 7

SP - 94

EP - 95

JO - Journal of Molecular Graphics

JF - Journal of Molecular Graphics

IS - 2

T2 - Conference Papers from the Symposium on Molecular Recognition: Its Role in Chemistry and Biochemistry

Y2 - 24 August 1988 through 27 August 1988

ER -

Steroid molecular structure and recognition by enzymes, receptors and binding proteins

Abstract

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