Step conductance increases in bilayer membranes induced by antibody-antigen-complement action

Darold Wobschall; Catherine McKeon

doi:10.1016/0005-2736(75)90117-0

Step conductance increases in bilayer membranes induced by antibody-antigen-complement action

Darold Wobschall
, Catherine McKeon

Department of Electrical Engineering

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

A sharp rise in the electrical conductance of lipid bilayer membranes was observed following the addition of antigen (bovine serum), antibody (rabbit anti-bovine serum), and complement to the neighboring aqueous phases. At low concentrations, step increases in the conductivity occurred which are consistent with the appearance of about 2.2 nm holes in the membrane. Probably attack or lysis of the lipid bilayer by complement is responsible.

Original language	English
Pages (from-to)	317-321
Number of pages	5
Journal	Biochimica et Biophysica Acta - Biomembranes
Volume	413
Issue number	2
DOIs	https://doi.org/10.1016/0005-2736(75)90117-0
State	Published - Dec 1 1975

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title = "Step conductance increases in bilayer membranes induced by antibody-antigen-complement action",

abstract = "A sharp rise in the electrical conductance of lipid bilayer membranes was observed following the addition of antigen (bovine serum), antibody (rabbit anti-bovine serum), and complement to the neighboring aqueous phases. At low concentrations, step increases in the conductivity occurred which are consistent with the appearance of about 2.2 nm holes in the membrane. Probably attack or lysis of the lipid bilayer by complement is responsible.",

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AU - McKeon, Catherine

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N2 - A sharp rise in the electrical conductance of lipid bilayer membranes was observed following the addition of antigen (bovine serum), antibody (rabbit anti-bovine serum), and complement to the neighboring aqueous phases. At low concentrations, step increases in the conductivity occurred which are consistent with the appearance of about 2.2 nm holes in the membrane. Probably attack or lysis of the lipid bilayer by complement is responsible.

AB - A sharp rise in the electrical conductance of lipid bilayer membranes was observed following the addition of antigen (bovine serum), antibody (rabbit anti-bovine serum), and complement to the neighboring aqueous phases. At low concentrations, step increases in the conductivity occurred which are consistent with the appearance of about 2.2 nm holes in the membrane. Probably attack or lysis of the lipid bilayer by complement is responsible.

UR - https://www.scopus.com/pages/publications/0016716576

U2 - 10.1016/0005-2736(75)90117-0

DO - 10.1016/0005-2736(75)90117-0

M3 - Article

C2 - 1238122

AN - SCOPUS:0016716576

SN - 0005-2736

VL - 413

SP - 317

EP - 321

JO - Biochimica et Biophysica Acta - Biomembranes

JF - Biochimica et Biophysica Acta - Biomembranes

IS - 2

ER -

Step conductance increases in bilayer membranes induced by antibody-antigen-complement action

Abstract

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