Abstract
The effects of concentration, temperature and silver nitrate addition on nitroglycerin stability in human plasma were examined. Degradation of nitroglycerin in rat plasma was also studied as functions of temperature and red blood cell hemolysis. Depending upon the temperature, nitroglycerin is 10-50 times more stable in human plasma than in rat plasma. Significant drug degradation, i.e. 10% loss in 40 days, still occurs when human plasma samples containing nitroglycerin are stored at -20°C. Nitroglycerin degradation in plasma apparently follows first-order kinetics and the Arrhenius relationship, and is independent of concentration up to about 150 ng/ml. Addition of silver nitrate to human plasma produced a significant increase in nitroglycerin stability. Hemolysis in rat plasma did not drastically increase nitroglycerin degradation.
| Original language | English |
|---|---|
| Pages (from-to) | 75-82 |
| Number of pages | 8 |
| Journal | International Journal of Pharmaceutics |
| Volume | 4 |
| Issue number | 1 |
| DOIs | |
| State | Published - Nov 1979 |
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