Solution NMR structure of the helicase associated domain BVU-0683(627-691) from Bacteroides vulgatus provides first structural coverage for protein domain family PF03457 and indicates domain binding to DNA

Jeffrey L. Mills; Thomas B. Acton; Rong Xiao; John K. Everett; Gaetano T. Montelione; Thomas Szyperski

doi:10.1007/s10969-012-9148-0

Solution NMR structure of the helicase associated domain BVU-0683(627-691) from Bacteroides vulgatus provides first structural coverage for protein domain family PF03457 and indicates domain binding to DNA

Jeffrey L. Mills
, Thomas B. Acton
, Rong Xiao
, John K. Everett
, Gaetano T. Montelione
, Thomas Szyperski

Chemistry

SUNY Buffalo
Rutgers - The State University of New Jersey, New Brunswick

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A high-quality NMR structure of the helicase associated (HA) domain comprising residues 627-691 of the 753-residue protein BVU-0683 from Bacteroides vulgatus exhibits an all α-helical fold. The structure presented here is the first representative for the large protein domain family PF03457 (currently 742 members) of HA domains. Comparison with structurally similar proteins supports the hypothesis that HA domains bind to DNA and that binding specificity varies greatly within the family of HA domains constituting PF03457.

Original language	English
Pages (from-to)	19-24
Number of pages	6
Journal	Journal of Structural and Functional Genomics
Volume	14
Issue number	1
DOIs	https://doi.org/10.1007/s10969-012-9148-0
State	Published - Mar 2013

Keywords

A6KY75-BACV8
BVU-0683
Helicase associated domain
PF03457
SANT domain
Structural genomics

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10.1007/s10969-012-9148-0

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Mills, J. L., Acton, T. B., Xiao, R., Everett, J. K., Montelione, G. T., & Szyperski, T. (2013). Solution NMR structure of the helicase associated domain BVU-0683(627-691) from Bacteroides vulgatus provides first structural coverage for protein domain family PF03457 and indicates domain binding to DNA. Journal of Structural and Functional Genomics, 14(1), 19-24. https://doi.org/10.1007/s10969-012-9148-0

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title = "Solution NMR structure of the helicase associated domain BVU-0683(627-691) from Bacteroides vulgatus provides first structural coverage for protein domain family PF03457 and indicates domain binding to DNA",

abstract = "A high-quality NMR structure of the helicase associated (HA) domain comprising residues 627-691 of the 753-residue protein BVU-0683 from Bacteroides vulgatus exhibits an all α-helical fold. The structure presented here is the first representative for the large protein domain family PF03457 (currently 742 members) of HA domains. Comparison with structurally similar proteins supports the hypothesis that HA domains bind to DNA and that binding specificity varies greatly within the family of HA domains constituting PF03457.",

keywords = "A6KY75-BACV8, BVU-0683, Helicase associated domain, PF03457, SANT domain, Structural genomics",

author = "Mills, \{Jeffrey L.\} and Acton, \{Thomas B.\} and Rong Xiao and Everett, \{John K.\} and Montelione, \{Gaetano T.\} and Thomas Szyperski",

year = "2013",

month = mar,

doi = "10.1007/s10969-012-9148-0",

language = "English",

volume = "14",

pages = "19--24",

journal = "Journal of Structural and Functional Genomics",

issn = "1345-711X",

publisher = "Springer Netherlands",

number = "1",

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Mills, JL, Acton, TB, Xiao, R, Everett, JK, Montelione, GT & Szyperski, T 2013, 'Solution NMR structure of the helicase associated domain BVU-0683(627-691) from Bacteroides vulgatus provides first structural coverage for protein domain family PF03457 and indicates domain binding to DNA', Journal of Structural and Functional Genomics, vol. 14, no. 1, pp. 19-24. https://doi.org/10.1007/s10969-012-9148-0

Solution NMR structure of the helicase associated domain BVU-0683(627-691) from Bacteroides vulgatus provides first structural coverage for protein domain family PF03457 and indicates domain binding to DNA. / Mills, Jeffrey L.; Acton, Thomas B.; Xiao, Rong et al.
In: Journal of Structural and Functional Genomics, Vol. 14, No. 1, 03.2013, p. 19-24.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Solution NMR structure of the helicase associated domain BVU-0683(627-691) from Bacteroides vulgatus provides first structural coverage for protein domain family PF03457 and indicates domain binding to DNA

AU - Mills, Jeffrey L.

AU - Acton, Thomas B.

AU - Xiao, Rong

AU - Everett, John K.

AU - Montelione, Gaetano T.

AU - Szyperski, Thomas

PY - 2013/3

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N2 - A high-quality NMR structure of the helicase associated (HA) domain comprising residues 627-691 of the 753-residue protein BVU-0683 from Bacteroides vulgatus exhibits an all α-helical fold. The structure presented here is the first representative for the large protein domain family PF03457 (currently 742 members) of HA domains. Comparison with structurally similar proteins supports the hypothesis that HA domains bind to DNA and that binding specificity varies greatly within the family of HA domains constituting PF03457.

AB - A high-quality NMR structure of the helicase associated (HA) domain comprising residues 627-691 of the 753-residue protein BVU-0683 from Bacteroides vulgatus exhibits an all α-helical fold. The structure presented here is the first representative for the large protein domain family PF03457 (currently 742 members) of HA domains. Comparison with structurally similar proteins supports the hypothesis that HA domains bind to DNA and that binding specificity varies greatly within the family of HA domains constituting PF03457.

KW - A6KY75-BACV8

KW - BVU-0683

KW - Helicase associated domain

KW - PF03457

KW - SANT domain

KW - Structural genomics

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DO - 10.1007/s10969-012-9148-0

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AN - SCOPUS:84876793330

SN - 1345-711X

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SP - 19

EP - 24

JO - Journal of Structural and Functional Genomics

JF - Journal of Structural and Functional Genomics

IS - 1

ER -

Mills JL, Acton TB, Xiao R, Everett JK, Montelione GT, Szyperski T. Solution NMR structure of the helicase associated domain BVU-0683(627-691) from Bacteroides vulgatus provides first structural coverage for protein domain family PF03457 and indicates domain binding to DNA. Journal of Structural and Functional Genomics. 2013 Mar;14(1):19-24. doi: 10.1007/s10969-012-9148-0

Solution NMR structure of the helicase associated domain BVU-0683(627-691) from Bacteroides vulgatus provides first structural coverage for protein domain family PF03457 and indicates domain binding to DNA

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Keywords

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