Singlet Oxygen Generation via Two-Photon Excited FRET

William R. Dichtel; Jason M. Serin; Carine Edder; Jean M.J. Fréchet; Michael Matuszewski; Loon Seng Tan; Tymish Y. Ohulchanskyy; Paras N. Prasad

doi:10.1021/ja031647x

Singlet Oxygen Generation via Two-Photon Excited FRET

William R. Dichtel
, Jason M. Serin
, Carine Edder
, Jean M.J. Fréchet
, Michael Matuszewski
, Loon Seng Tan
, Tymish Y. Ohulchanskyy
, Paras N. Prasad

University of California at Berkeley
Air Force Research Laboratory

Research output: Contribution to journal › Article › peer-review

240 Scopus citations

Abstract

A new approach to two-photon excited photodynamic therapy has been developed. A dendritic array of eight donor chromophores capable of two-photon absorption (TPA) was covalently attached to a central porphyrin acceptor. Steady-state fluorescence measurements demonstrated that the donor chromophores transfer excited-state energy to the porphyrin with 97% efficiency. Two-photon excitation of the donor chromophores at 780 nm resulted in a dramatic increase in porphyrin fluorescence relative to a porphyrin model compound. Enhanced singlet oxygen luminescence was observed from oxygen-saturated solutions of the target compound under two-photon excitation conditions.

Original language	English
Pages (from-to)	5380-5381
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	126
Issue number	17
DOIs	https://doi.org/10.1021/ja031647x
State	Published - May 5 2004

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@article{9079d8bbfaec4027948cf6d07111dba3,

title = "Singlet Oxygen Generation via Two-Photon Excited FRET",

abstract = "A new approach to two-photon excited photodynamic therapy has been developed. A dendritic array of eight donor chromophores capable of two-photon absorption (TPA) was covalently attached to a central porphyrin acceptor. Steady-state fluorescence measurements demonstrated that the donor chromophores transfer excited-state energy to the porphyrin with 97\% efficiency. Two-photon excitation of the donor chromophores at 780 nm resulted in a dramatic increase in porphyrin fluorescence relative to a porphyrin model compound. Enhanced singlet oxygen luminescence was observed from oxygen-saturated solutions of the target compound under two-photon excitation conditions.",

author = "Dichtel, \{William R.\} and Serin, \{Jason M.\} and Carine Edder and Fr{\'e}chet, \{Jean M.J.\} and Michael Matuszewski and Tan, \{Loon Seng\} and Ohulchanskyy, \{Tymish Y.\} and Prasad, \{Paras N.\}",

year = "2004",

month = may,

day = "5",

doi = "10.1021/ja031647x",

language = "English",

volume = "126",

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TY - JOUR

T1 - Singlet Oxygen Generation via Two-Photon Excited FRET

AU - Dichtel, William R.

AU - Serin, Jason M.

AU - Edder, Carine

AU - Fréchet, Jean M.J.

AU - Matuszewski, Michael

AU - Tan, Loon Seng

AU - Ohulchanskyy, Tymish Y.

AU - Prasad, Paras N.

PY - 2004/5/5

Y1 - 2004/5/5

N2 - A new approach to two-photon excited photodynamic therapy has been developed. A dendritic array of eight donor chromophores capable of two-photon absorption (TPA) was covalently attached to a central porphyrin acceptor. Steady-state fluorescence measurements demonstrated that the donor chromophores transfer excited-state energy to the porphyrin with 97% efficiency. Two-photon excitation of the donor chromophores at 780 nm resulted in a dramatic increase in porphyrin fluorescence relative to a porphyrin model compound. Enhanced singlet oxygen luminescence was observed from oxygen-saturated solutions of the target compound under two-photon excitation conditions.

AB - A new approach to two-photon excited photodynamic therapy has been developed. A dendritic array of eight donor chromophores capable of two-photon absorption (TPA) was covalently attached to a central porphyrin acceptor. Steady-state fluorescence measurements demonstrated that the donor chromophores transfer excited-state energy to the porphyrin with 97% efficiency. Two-photon excitation of the donor chromophores at 780 nm resulted in a dramatic increase in porphyrin fluorescence relative to a porphyrin model compound. Enhanced singlet oxygen luminescence was observed from oxygen-saturated solutions of the target compound under two-photon excitation conditions.

UR - https://www.scopus.com/pages/publications/2342636314

U2 - 10.1021/ja031647x

DO - 10.1021/ja031647x

M3 - Article

AN - SCOPUS:2342636314

SN - 0002-7863

VL - 126

SP - 5380

EP - 5381

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 17

ER -

Singlet Oxygen Generation via Two-Photon Excited FRET

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