Silencers, Enhancers, and the Multifunctional Regulatory Genome

Marc S. Halfon

doi:10.1016/j.tig.2019.12.005

Silencers, Enhancers, and the Multifunctional Regulatory Genome

Marc S. Halfon

Biochemistry

Research output: Contribution to journal › Short survey › peer-review

28 Scopus citations

Abstract

Negative regulation of gene expression by transcriptional silencers has been difficult to study due to limited defined examples. A new study by Gisselbrecht et al. has dramatically increased the number of identified silencers and reveals that they are bifunctional regulatory sequences that also act as gene expression-promoting enhancers.

Original language	English
Pages (from-to)	149-151
Number of pages	3
Journal	Trends in Genetics
Volume	36
Issue number	3
DOIs	https://doi.org/10.1016/j.tig.2019.12.005
State	Published - Mar 2020

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title = "Silencers, Enhancers, and the Multifunctional Regulatory Genome",

abstract = "Negative regulation of gene expression by transcriptional silencers has been difficult to study due to limited defined examples. A new study by Gisselbrecht et al. has dramatically increased the number of identified silencers and reveals that they are bifunctional regulatory sequences that also act as gene expression-promoting enhancers.",

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AB - Negative regulation of gene expression by transcriptional silencers has been difficult to study due to limited defined examples. A new study by Gisselbrecht et al. has dramatically increased the number of identified silencers and reveals that they are bifunctional regulatory sequences that also act as gene expression-promoting enhancers.

UR - https://www.scopus.com/pages/publications/85077613575

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DO - 10.1016/j.tig.2019.12.005

M3 - Short survey

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Silencers, Enhancers, and the Multifunctional Regulatory Genome

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