Shiftwork and Biomarkers of Subclinical Cardiovascular Disease: The BCOPS Study

Meghan M. Holst; Michael D. Wirth; Anna Mnatsakanova; James B. Burch; Luenda E. Charles; Cathy Tinney-Zara; Desta Fekedulegn; Michael E. Andrew; Tara A. Hartley; John M. Violanti

doi:10.1097/JOM.0000000000001541

Shiftwork and Biomarkers of Subclinical Cardiovascular Disease: The BCOPS Study

Meghan M. Holst
, Michael D. Wirth
, Anna Mnatsakanova
, James B. Burch
, Luenda E. Charles
, Cathy Tinney-Zara
, Desta Fekedulegn
, Michael E. Andrew
, Tara A. Hartley
, John M. Violanti

Department of Epidemiology and Environmental Health

University of South Carolina
National Institute for Occupational Safety and Health
Department of Veterans Affairs

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Objective:To assess the association of shiftwork with biomarkers of subclinical cardiovascular disease and examine the moderating role of body mass index (BMI) in a police cohort.Methods:A cross-sectional analysis was conducted among officers who were categorized as working the day, evening, or night shift. Comparisons with inflammatory biomarkers were performed among shifts using analysis of variance/covariance and further stratified by BMI to assess potential effect modification.Results:Associations were observed between day and night shiftworkers for leukocytes, tumor necrosis factor alpha, and homocysteine. After BMI stratification, higher c-reactive protein (CRP) levels were observed among evening shiftworkers with a BMI more than or equal to 30kg/m² versus the day shift.Conclusions:Future studies examining prospective changes in these markers will allow for more comprehensive evaluation of their association with shiftwork.

Original language	English
Pages (from-to)	391-396
Number of pages	6
Journal	Journal of Occupational and Environmental Medicine
Volume	61
Issue number	5
DOIs	https://doi.org/10.1097/JOM.0000000000001541
State	Published - May 1 2019

Keywords

Cardiovascular disease
Inflammation
Police work
Shiftwork

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10.1097/JOM.0000000000001541

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@article{a95abeba098b4edc8a301ea2ad886222,

title = "Shiftwork and Biomarkers of Subclinical Cardiovascular Disease: The BCOPS Study",

abstract = "Objective:To assess the association of shiftwork with biomarkers of subclinical cardiovascular disease and examine the moderating role of body mass index (BMI) in a police cohort.Methods:A cross-sectional analysis was conducted among officers who were categorized as working the day, evening, or night shift. Comparisons with inflammatory biomarkers were performed among shifts using analysis of variance/covariance and further stratified by BMI to assess potential effect modification.Results:Associations were observed between day and night shiftworkers for leukocytes, tumor necrosis factor alpha, and homocysteine. After BMI stratification, higher c-reactive protein (CRP) levels were observed among evening shiftworkers with a BMI more than or equal to 30kg/m2 versus the day shift.Conclusions:Future studies examining prospective changes in these markers will allow for more comprehensive evaluation of their association with shiftwork.",

keywords = "Cardiovascular disease, Inflammation, Police work, Shiftwork",

author = "Holst, \{Meghan M.\} and Wirth, \{Michael D.\} and Anna Mnatsakanova and Burch, \{James B.\} and Charles, \{Luenda E.\} and Cathy Tinney-Zara and Desta Fekedulegn and Andrew, \{Michael E.\} and Hartley, \{Tara A.\} and Violanti, \{John M.\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2019 American College of Occupational and Environmental Medicine.",

year = "2019",

month = may,

day = "1",

doi = "10.1097/JOM.0000000000001541",

language = "English",

volume = "61",

pages = "391--396",

journal = "Journal of Occupational and Environmental Medicine",

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TY - JOUR

T1 - Shiftwork and Biomarkers of Subclinical Cardiovascular Disease

T2 - The BCOPS Study

AU - Holst, Meghan M.

AU - Wirth, Michael D.

AU - Mnatsakanova, Anna

AU - Burch, James B.

AU - Charles, Luenda E.

AU - Tinney-Zara, Cathy

AU - Fekedulegn, Desta

AU - Andrew, Michael E.

AU - Hartley, Tara A.

AU - Violanti, John M.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Objective:To assess the association of shiftwork with biomarkers of subclinical cardiovascular disease and examine the moderating role of body mass index (BMI) in a police cohort.Methods:A cross-sectional analysis was conducted among officers who were categorized as working the day, evening, or night shift. Comparisons with inflammatory biomarkers were performed among shifts using analysis of variance/covariance and further stratified by BMI to assess potential effect modification.Results:Associations were observed between day and night shiftworkers for leukocytes, tumor necrosis factor alpha, and homocysteine. After BMI stratification, higher c-reactive protein (CRP) levels were observed among evening shiftworkers with a BMI more than or equal to 30kg/m2 versus the day shift.Conclusions:Future studies examining prospective changes in these markers will allow for more comprehensive evaluation of their association with shiftwork.

AB - Objective:To assess the association of shiftwork with biomarkers of subclinical cardiovascular disease and examine the moderating role of body mass index (BMI) in a police cohort.Methods:A cross-sectional analysis was conducted among officers who were categorized as working the day, evening, or night shift. Comparisons with inflammatory biomarkers were performed among shifts using analysis of variance/covariance and further stratified by BMI to assess potential effect modification.Results:Associations were observed between day and night shiftworkers for leukocytes, tumor necrosis factor alpha, and homocysteine. After BMI stratification, higher c-reactive protein (CRP) levels were observed among evening shiftworkers with a BMI more than or equal to 30kg/m2 versus the day shift.Conclusions:Future studies examining prospective changes in these markers will allow for more comprehensive evaluation of their association with shiftwork.

KW - Cardiovascular disease

KW - Inflammation

KW - Police work

KW - Shiftwork

UR - https://www.scopus.com/pages/publications/85069268723

U2 - 10.1097/JOM.0000000000001541

DO - 10.1097/JOM.0000000000001541

M3 - Article

C2 - 30649009

AN - SCOPUS:85069268723

SN - 1076-2752

VL - 61

SP - 391

EP - 396

JO - Journal of Occupational and Environmental Medicine

JF - Journal of Occupational and Environmental Medicine

IS - 5

ER -

Shiftwork and Biomarkers of Subclinical Cardiovascular Disease: The BCOPS Study

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Keywords

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