Shared genetics underlying epidemiological association between endometriosis and ovarian cancer

Australian Ovarian Cancer Study; The International Endogene Consortium(IEC)

doi:10.1093/hmg/ddv306

Shared genetics underlying epidemiological association between endometriosis and ovarian cancer

Australian Ovarian Cancer Study
, The International Endogene Consortium(IEC)

Department of Epidemiology and Environmental Health

Statistical Genetics
Queensland Institute of Medical Research
Queensland University of Technology
University of Liverpool
University of Oxford
University of California at Los Angeles
Friedrich-Alexander University Erlangen-Nürnberg
KU Leuven
Flanders Institute for Biotechnology
Dartmouth College
University of Washington
Fred Hutchinson Cancer Research Center
German Cancer Research Center
Ulm University
Samuel Oschin Comprehensive Cancer Institute
Cedars-Sinai Medical Center
Hannover Medical School
Friedrich Schiller University Jena
N.N. Alexandrov National Cancer Centre of Belarus
University of Helsinki
University of Pittsburgh
University of Texas Health Science Center at Houston
Roswell Park Cancer Institute
Danish Cancer Society
University of Copenhagen
Monash University
University of Melbourne
Cancer Council Victoria
University of Texas MD Anderson Cancer Center
Texas Southern University
Memorial Sloan-Kettering Cancer Center
Brigham and Women’s Hospital

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Epidemiological studies have demonstrated associations between endometriosis and certain histotypes of ovarian cancer, including clear cell, low-grade serous and endometrioid carcinomas. We aimed to determine whether the observed associations might be due to shared genetic aetiology. To address this, we used two endometriosis datasets genotyped on common arrays with full-genome coverage (3194 cases and 7060 controls) and a large ovarian cancer dataset genotyped on the customized Illumina Infinium iSelect (iCOGS) arrays (10 065 cases and 21 663 controls). Previous work has suggested that a large number of genetic variants contribute to endometriosis and ovarian cancer (all histotypes combined) susceptibility. Here, using the iCOGS data, we confirmed polygenic architecture for most histotypes of ovarian cancer. This led us to evaluate if the polygenic effects are shared across diseases. We found evidence for shared genetic risks between endometriosis and all histotypes of ovarian cancer, except for the intestinal mucinous type. Clear cell carcinoma showed the strongest genetic correlation with endometriosis (0.51, 95% CI = 0.18-0.84). Endometrioid and low-grade serous carcinomas had similar correlation coefficients (0.48, 95% CI = 0.07-0.89 and 0.40, 95% CI = 0.05-0.75, respectively). High-grade serous carcinoma, which often arises from the fallopian tubes, showed a weaker genetic correlation with endometriosis (0.25, 95% CI = 0.11-0.39), despite the absence of a known epidemiological association. These results suggest that the epidemiological association between endometriosis and ovarian adenocarcinoma may be attributable to shared genetic susceptibility loci.

Original language	English
Pages (from-to)	5955-5964
Number of pages	10
Journal	Human Molecular Genetics
Volume	24
Issue number	20
DOIs	https://doi.org/10.1093/hmg/ddv306
State	Published - Jun 5 2015

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10.1093/hmg/ddv306

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@article{b787fb2e5442468f949038a5222a9241,

title = "Shared genetics underlying epidemiological association between endometriosis and ovarian cancer",

abstract = "Epidemiological studies have demonstrated associations between endometriosis and certain histotypes of ovarian cancer, including clear cell, low-grade serous and endometrioid carcinomas. We aimed to determine whether the observed associations might be due to shared genetic aetiology. To address this, we used two endometriosis datasets genotyped on common arrays with full-genome coverage (3194 cases and 7060 controls) and a large ovarian cancer dataset genotyped on the customized Illumina Infinium iSelect (iCOGS) arrays (10 065 cases and 21 663 controls). Previous work has suggested that a large number of genetic variants contribute to endometriosis and ovarian cancer (all histotypes combined) susceptibility. Here, using the iCOGS data, we confirmed polygenic architecture for most histotypes of ovarian cancer. This led us to evaluate if the polygenic effects are shared across diseases. We found evidence for shared genetic risks between endometriosis and all histotypes of ovarian cancer, except for the intestinal mucinous type. Clear cell carcinoma showed the strongest genetic correlation with endometriosis (0.51, 95\% CI = 0.18-0.84). Endometrioid and low-grade serous carcinomas had similar correlation coefficients (0.48, 95\% CI = 0.07-0.89 and 0.40, 95\% CI = 0.05-0.75, respectively). High-grade serous carcinoma, which often arises from the fallopian tubes, showed a weaker genetic correlation with endometriosis (0.25, 95\% CI = 0.11-0.39), despite the absence of a known epidemiological association. These results suggest that the epidemiological association between endometriosis and ovarian adenocarcinoma may be attributable to shared genetic susceptibility loci.",

author = "\{Australian Ovarian Cancer Study\} and \{The International Endogene Consortium(IEC)\} and Yi Lu and Gabriel Cuellar-Partida and Painter, \{Jodie N.\} and Nyholt, \{Dale R.\} and Morris, \{Andrew P.\} and Fasching, \{Peter A.\} and Alexander Hein and Stefanie Burghaus and Beckmann, \{Matthias W.\} and Diether Lambrechts and \{Van Nieuwenhuysen\}, Els and Ignace Vergote and Adriaan Vanderstichele and Doherty, \{Jennifer Anne\} and Rossing, \{Mary Anne\} and Wicklund, \{Kristine G.\} and Jenny Chang-Claude and Ursula Eilber and Anja Rudolph and Shan Wang-Gohrke and Goodman, \{Marc T.\} and Natalia Bogdanova and Thilo D{\"o}rk and Matthias D{\"u}rst and Peter Hillemanns and Runnebaum, \{Ingo B.\} and Natalia Antonenkova and Ralf Butzow and Arto Leminen and Heli Nevanlinna and Pelttari, \{Liisa M.\} and Edwards, \{Robert P.\} and Kelley, \{Joseph L.\} and Francesmary Modugno and Moysich, \{Kirsten B.\} and Ness, \{Roberta B.\} and Rikki Cannioto and Estrid H{\o}gdall and Allan Jensen and Giles, \{Graham G.\} and Fiona Bruinsma and Kjaer, \{Susanne K.\} and Hildebrandt, \{Michelle A.T.\} and Dong Liang and Lu, \{Karen H.\} and Xifeng Wu and Maria Bisogna and Fanny Dao and Levine, \{Douglas A.\} and Cramer, \{Daniel W.\}",

note = "Publisher Copyright: {\textcopyright} The Author 2015.",

year = "2015",

month = jun,

day = "5",

doi = "10.1093/hmg/ddv306",

language = "English",

volume = "24",

pages = "5955--5964",

journal = "Human Molecular Genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

number = "20",

}

TY - JOUR

T1 - Shared genetics underlying epidemiological association between endometriosis and ovarian cancer

AU - Australian Ovarian Cancer Study

AU - The International Endogene Consortium(IEC)

AU - Lu, Yi

AU - Cuellar-Partida, Gabriel

AU - Painter, Jodie N.

AU - Nyholt, Dale R.

AU - Morris, Andrew P.

AU - Fasching, Peter A.

AU - Hein, Alexander

AU - Burghaus, Stefanie

AU - Beckmann, Matthias W.

AU - Lambrechts, Diether

AU - Van Nieuwenhuysen, Els

AU - Vergote, Ignace

AU - Vanderstichele, Adriaan

AU - Doherty, Jennifer Anne

AU - Rossing, Mary Anne

AU - Wicklund, Kristine G.

AU - Chang-Claude, Jenny

AU - Eilber, Ursula

AU - Rudolph, Anja

AU - Wang-Gohrke, Shan

AU - Goodman, Marc T.

AU - Bogdanova, Natalia

AU - Dörk, Thilo

AU - Dürst, Matthias

AU - Hillemanns, Peter

AU - Runnebaum, Ingo B.

AU - Antonenkova, Natalia

AU - Butzow, Ralf

AU - Leminen, Arto

AU - Nevanlinna, Heli

AU - Pelttari, Liisa M.

AU - Edwards, Robert P.

AU - Kelley, Joseph L.

AU - Modugno, Francesmary

AU - Moysich, Kirsten B.

AU - Ness, Roberta B.

AU - Cannioto, Rikki

AU - Høgdall, Estrid

AU - Jensen, Allan

AU - Giles, Graham G.

AU - Bruinsma, Fiona

AU - Kjaer, Susanne K.

AU - Hildebrandt, Michelle A.T.

AU - Liang, Dong

AU - Lu, Karen H.

AU - Wu, Xifeng

AU - Bisogna, Maria

AU - Dao, Fanny

AU - Levine, Douglas A.

AU - Cramer, Daniel W.

PY - 2015/6/5

Y1 - 2015/6/5

N2 - Epidemiological studies have demonstrated associations between endometriosis and certain histotypes of ovarian cancer, including clear cell, low-grade serous and endometrioid carcinomas. We aimed to determine whether the observed associations might be due to shared genetic aetiology. To address this, we used two endometriosis datasets genotyped on common arrays with full-genome coverage (3194 cases and 7060 controls) and a large ovarian cancer dataset genotyped on the customized Illumina Infinium iSelect (iCOGS) arrays (10 065 cases and 21 663 controls). Previous work has suggested that a large number of genetic variants contribute to endometriosis and ovarian cancer (all histotypes combined) susceptibility. Here, using the iCOGS data, we confirmed polygenic architecture for most histotypes of ovarian cancer. This led us to evaluate if the polygenic effects are shared across diseases. We found evidence for shared genetic risks between endometriosis and all histotypes of ovarian cancer, except for the intestinal mucinous type. Clear cell carcinoma showed the strongest genetic correlation with endometriosis (0.51, 95% CI = 0.18-0.84). Endometrioid and low-grade serous carcinomas had similar correlation coefficients (0.48, 95% CI = 0.07-0.89 and 0.40, 95% CI = 0.05-0.75, respectively). High-grade serous carcinoma, which often arises from the fallopian tubes, showed a weaker genetic correlation with endometriosis (0.25, 95% CI = 0.11-0.39), despite the absence of a known epidemiological association. These results suggest that the epidemiological association between endometriosis and ovarian adenocarcinoma may be attributable to shared genetic susceptibility loci.

AB - Epidemiological studies have demonstrated associations between endometriosis and certain histotypes of ovarian cancer, including clear cell, low-grade serous and endometrioid carcinomas. We aimed to determine whether the observed associations might be due to shared genetic aetiology. To address this, we used two endometriosis datasets genotyped on common arrays with full-genome coverage (3194 cases and 7060 controls) and a large ovarian cancer dataset genotyped on the customized Illumina Infinium iSelect (iCOGS) arrays (10 065 cases and 21 663 controls). Previous work has suggested that a large number of genetic variants contribute to endometriosis and ovarian cancer (all histotypes combined) susceptibility. Here, using the iCOGS data, we confirmed polygenic architecture for most histotypes of ovarian cancer. This led us to evaluate if the polygenic effects are shared across diseases. We found evidence for shared genetic risks between endometriosis and all histotypes of ovarian cancer, except for the intestinal mucinous type. Clear cell carcinoma showed the strongest genetic correlation with endometriosis (0.51, 95% CI = 0.18-0.84). Endometrioid and low-grade serous carcinomas had similar correlation coefficients (0.48, 95% CI = 0.07-0.89 and 0.40, 95% CI = 0.05-0.75, respectively). High-grade serous carcinoma, which often arises from the fallopian tubes, showed a weaker genetic correlation with endometriosis (0.25, 95% CI = 0.11-0.39), despite the absence of a known epidemiological association. These results suggest that the epidemiological association between endometriosis and ovarian adenocarcinoma may be attributable to shared genetic susceptibility loci.

UR - https://www.scopus.com/pages/publications/84943745699

U2 - 10.1093/hmg/ddv306

DO - 10.1093/hmg/ddv306

M3 - Article

C2 - 26231222

AN - SCOPUS:84943745699

SN - 0964-6906

VL - 24

SP - 5955

EP - 5964

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 20

ER -

Shared genetics underlying epidemiological association between endometriosis and ovarian cancer

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