Sex differences in late behavioral response to subcutaneous formalin injection in mice

Susan Jin Kim; Amelita A. Calejesan; Ping Li; Feng Wei; Min Zhuo

doi:10.1016/S0006-8993(99)01353-0

Sex differences in late behavioral response to subcutaneous formalin injection in mice

Susan Jin Kim
, Amelita A. Calejesan
, Ping Li
, Feng Wei
, Min Zhuo

Neurology

Washington University St. Louis

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

We investigated sex- or gender-dependent differences in nociception using the formalin test in mice. In addition to typical biphasic responses, a new, late phase (Phase 3) was observed. A local anesthetic QX-314 injected at the end of Phase 2 blocked Phase 3. Phase 3 in female mice was significantly greater than that in male mice regardless the stage of the estrus cycle.

Original language	English
Pages (from-to)	185-189
Number of pages	5
Journal	Brain Research
Volume	829
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(99)01353-0
State	Published - May 22 1999

Keywords

Formalin test
Gender-related difference
Mouse
Persistent pain

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10.1016/S0006-8993(99)01353-0

Cite this

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abstract = "We investigated sex- or gender-dependent differences in nociception using the formalin test in mice. In addition to typical biphasic responses, a new, late phase (Phase 3) was observed. A local anesthetic QX-314 injected at the end of Phase 2 blocked Phase 3. Phase 3 in female mice was significantly greater than that in male mice regardless the stage of the estrus cycle.",

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AU - Kim, Susan Jin

AU - Calejesan, Amelita A.

AU - Li, Ping

AU - Wei, Feng

AU - Zhuo, Min

PY - 1999/5/22

Y1 - 1999/5/22

N2 - We investigated sex- or gender-dependent differences in nociception using the formalin test in mice. In addition to typical biphasic responses, a new, late phase (Phase 3) was observed. A local anesthetic QX-314 injected at the end of Phase 2 blocked Phase 3. Phase 3 in female mice was significantly greater than that in male mice regardless the stage of the estrus cycle.

AB - We investigated sex- or gender-dependent differences in nociception using the formalin test in mice. In addition to typical biphasic responses, a new, late phase (Phase 3) was observed. A local anesthetic QX-314 injected at the end of Phase 2 blocked Phase 3. Phase 3 in female mice was significantly greater than that in male mice regardless the stage of the estrus cycle.

KW - Formalin test

KW - Gender-related difference

KW - Mouse

KW - Persistent pain

UR - https://www.scopus.com/pages/publications/0344258120

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DO - 10.1016/S0006-8993(99)01353-0

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ER -

Sex differences in late behavioral response to subcutaneous formalin injection in mice

Abstract

Keywords

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