Serum protein binding of prednisolone in four species

Mario L. Rocci; Noreen F. Johnson; William J. Jusko

doi:10.1002/jps.2600690831

Serum protein binding of prednisolone in four species

Mario L. Rocci
, Noreen F. Johnson
, William J. Jusko

Pharmaceutical Sciences

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

The protein binding of prednisolone in serum from humans, rabbits, dogs, and rats was determined by equilibrium dialysis. Two nonlinear least‐squares regression programs were used to characterize transcortin and albumin binding of the steroid. The animal species differed markedly in their ability to bind prednisolone, but the rabbit was most similar to humans in transcortin concentration and affinity constant.

Original language	English
Pages (from-to)	977-978
Number of pages	2
Journal	Journal of Pharmaceutical Sciences
Volume	69
Issue number	8
DOIs	https://doi.org/10.1002/jps.2600690831
State	Published - Aug 1980

Keywords

Binding, serum protein—prednisolone in humans, rabbits, dogs, and rats
Prednisolone—serum protein binding in humans, rabbits, dogs, and rats
Serum protein binding—prednisolone in humans, rabbits, dogs, and rats

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10.1002/jps.2600690831

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title = "Serum protein binding of prednisolone in four species",

abstract = "The protein binding of prednisolone in serum from humans, rabbits, dogs, and rats was determined by equilibrium dialysis. Two nonlinear least‐squares regression programs were used to characterize transcortin and albumin binding of the steroid. The animal species differed markedly in their ability to bind prednisolone, but the rabbit was most similar to humans in transcortin concentration and affinity constant.",

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author = "Rocci, \{Mario L.\} and Johnson, \{Noreen F.\} and Jusko, \{William J.\}",

year = "1980",

month = aug,

doi = "10.1002/jps.2600690831",

language = "English",

volume = "69",

pages = "977--978",

journal = "Journal of Pharmaceutical Sciences",

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T1 - Serum protein binding of prednisolone in four species

AU - Rocci, Mario L.

AU - Johnson, Noreen F.

AU - Jusko, William J.

PY - 1980/8

Y1 - 1980/8

N2 - The protein binding of prednisolone in serum from humans, rabbits, dogs, and rats was determined by equilibrium dialysis. Two nonlinear least‐squares regression programs were used to characterize transcortin and albumin binding of the steroid. The animal species differed markedly in their ability to bind prednisolone, but the rabbit was most similar to humans in transcortin concentration and affinity constant.

AB - The protein binding of prednisolone in serum from humans, rabbits, dogs, and rats was determined by equilibrium dialysis. Two nonlinear least‐squares regression programs were used to characterize transcortin and albumin binding of the steroid. The animal species differed markedly in their ability to bind prednisolone, but the rabbit was most similar to humans in transcortin concentration and affinity constant.

KW - Binding, serum protein—prednisolone in humans, rabbits, dogs, and rats

KW - Prednisolone—serum protein binding in humans, rabbits, dogs, and rats

KW - Serum protein binding—prednisolone in humans, rabbits, dogs, and rats

UR - https://www.scopus.com/pages/publications/0019129243

U2 - 10.1002/jps.2600690831

DO - 10.1002/jps.2600690831

M3 - Article

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VL - 69

SP - 977

EP - 978

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

IS - 8

ER -

Serum protein binding of prednisolone in four species

Abstract

Keywords

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