Serum Interferon Inhibitor Declines in Patients with HIV-1 Infection After a Change in Antiretroviral Therapy

Kailash C. Chadha; Stanley A. Schwartz; Madhavan P.N. Nair; Lisa R. Demeter; Ross G. Hewitt

doi:10.1081/IMM-120025107

Serum Interferon Inhibitor Declines in Patients with HIV-1 Infection After a Change in Antiretroviral Therapy

Kailash C. Chadha
, Stanley A. Schwartz
, Madhavan P.N. Nair
, Lisa R. Demeter
, Ross G. Hewitt

Medicine

Roswell Park Cancer Institute
Women and Children's Hospital of Buffalo
University of Rochester
State University of New York System

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

An inhibitor of interferon antiviral activity, which is absent in healthy HIV-seronegative persons, was detected in the sera of all 29 HIV-seropositive study participants. The relationship of the level of interferon inhibitor to CD4 count and HIV-RNA copy number was statistically significant in distinct models. Levels of interferon inhibitor declined by an average of 41-60% in patients who underwent a change in anti-retroviral therapy. Interferon inhibitor levels appear to decline as CD4 cell count rises and HIV-RNA levels fall. This suggests that interferon inhibitor may have a significant role in the host immune response to HIV infection.

Original language	English
Pages (from-to)	299-312
Number of pages	14
Journal	Immunological Investigations
Volume	32
Issue number	4
DOIs	https://doi.org/10.1081/IMM-120025107
State	Published - 2003

Keywords

Antiretroviral therapy
HIV-infection
HIV-RNA levels
Serum interferon inhibitor
Serum interferon levels

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10.1081/IMM-120025107

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title = "Serum Interferon Inhibitor Declines in Patients with HIV-1 Infection After a Change in Antiretroviral Therapy",

abstract = "An inhibitor of interferon antiviral activity, which is absent in healthy HIV-seronegative persons, was detected in the sera of all 29 HIV-seropositive study participants. The relationship of the level of interferon inhibitor to CD4 count and HIV-RNA copy number was statistically significant in distinct models. Levels of interferon inhibitor declined by an average of 41-60\% in patients who underwent a change in anti-retroviral therapy. Interferon inhibitor levels appear to decline as CD4 cell count rises and HIV-RNA levels fall. This suggests that interferon inhibitor may have a significant role in the host immune response to HIV infection.",

keywords = "Antiretroviral therapy, HIV-infection, HIV-RNA levels, Serum interferon inhibitor, Serum interferon levels",

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AU - Chadha, Kailash C.

AU - Schwartz, Stanley A.

AU - Nair, Madhavan P.N.

AU - Demeter, Lisa R.

AU - Hewitt, Ross G.

PY - 2003

Y1 - 2003

N2 - An inhibitor of interferon antiviral activity, which is absent in healthy HIV-seronegative persons, was detected in the sera of all 29 HIV-seropositive study participants. The relationship of the level of interferon inhibitor to CD4 count and HIV-RNA copy number was statistically significant in distinct models. Levels of interferon inhibitor declined by an average of 41-60% in patients who underwent a change in anti-retroviral therapy. Interferon inhibitor levels appear to decline as CD4 cell count rises and HIV-RNA levels fall. This suggests that interferon inhibitor may have a significant role in the host immune response to HIV infection.

AB - An inhibitor of interferon antiviral activity, which is absent in healthy HIV-seronegative persons, was detected in the sera of all 29 HIV-seropositive study participants. The relationship of the level of interferon inhibitor to CD4 count and HIV-RNA copy number was statistically significant in distinct models. Levels of interferon inhibitor declined by an average of 41-60% in patients who underwent a change in anti-retroviral therapy. Interferon inhibitor levels appear to decline as CD4 cell count rises and HIV-RNA levels fall. This suggests that interferon inhibitor may have a significant role in the host immune response to HIV infection.

KW - Antiretroviral therapy

KW - HIV-infection

KW - HIV-RNA levels

KW - Serum interferon inhibitor

KW - Serum interferon levels

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JO - Immunological Investigations

JF - Immunological Investigations

IS - 4

ER -

Serum Interferon Inhibitor Declines in Patients with HIV-1 Infection After a Change in Antiretroviral Therapy

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