Sensitive periods for hormonal programming of the brain

Geert J. De Vries; Christopher T. Fields; Nicole V. Peters; Jack Whylings; Matthew J. Paul

doi:10.1007/7854_2014_286

Sensitive periods for hormonal programming of the brain

Geert J. De Vries
, Christopher T. Fields
, Nicole V. Peters
, Jack Whylings
, Matthew J. Paul

Psychology

Georgia State University

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

During sensitive periods, information from the external and internal environment that occurs during particular phases of development is relayed to the brain to program neural development. Hormones play a central role in this process. In this review, we first discuss sexual differentiation of the brain as an example of hormonal programming. Using sexual differentiation, we define sensitive periods, review cellular and molecular processes that can explain their restricted temporal window, and discuss challenges in determining the precise timing of the temporal window. We then briefly review programming effects of other hormonal systems and discuss how programming of these systems interact with sexual differentiation.

Original language	English
Pages (from-to)	79-108
Number of pages	30
Journal	Current Topics in Behavioral Neurosciences
Volume	16
DOIs	https://doi.org/10.1007/7854_2014_286
State	Published - 2014

Keywords

Estrogen
HPA axis
Leptin
Neuroinflammation
Sexual differentiation
Testosterone
Vasopressin

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10.1007/7854_2014_286

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title = "Sensitive periods for hormonal programming of the brain",

abstract = "During sensitive periods, information from the external and internal environment that occurs during particular phases of development is relayed to the brain to program neural development. Hormones play a central role in this process. In this review, we first discuss sexual differentiation of the brain as an example of hormonal programming. Using sexual differentiation, we define sensitive periods, review cellular and molecular processes that can explain their restricted temporal window, and discuss challenges in determining the precise timing of the temporal window. We then briefly review programming effects of other hormonal systems and discuss how programming of these systems interact with sexual differentiation.",

keywords = "Estrogen, HPA axis, Leptin, Neuroinflammation, Sexual differentiation, Testosterone, Vasopressin",

author = "\{De Vries\}, \{Geert J.\} and Fields, \{Christopher T.\} and Peters, \{Nicole V.\} and Jack Whylings and Paul, \{Matthew J.\}",

note = "Publisher Copyright: {\textcopyright} Springer-Verlag Berlin Heidelberg 2014",

year = "2014",

doi = "10.1007/7854\_2014\_286",

language = "English",

volume = "16",

pages = "79--108",

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AU - De Vries, Geert J.

AU - Fields, Christopher T.

AU - Peters, Nicole V.

AU - Whylings, Jack

AU - Paul, Matthew J.

N1 - Publisher Copyright: © Springer-Verlag Berlin Heidelberg 2014

PY - 2014

Y1 - 2014

N2 - During sensitive periods, information from the external and internal environment that occurs during particular phases of development is relayed to the brain to program neural development. Hormones play a central role in this process. In this review, we first discuss sexual differentiation of the brain as an example of hormonal programming. Using sexual differentiation, we define sensitive periods, review cellular and molecular processes that can explain their restricted temporal window, and discuss challenges in determining the precise timing of the temporal window. We then briefly review programming effects of other hormonal systems and discuss how programming of these systems interact with sexual differentiation.

AB - During sensitive periods, information from the external and internal environment that occurs during particular phases of development is relayed to the brain to program neural development. Hormones play a central role in this process. In this review, we first discuss sexual differentiation of the brain as an example of hormonal programming. Using sexual differentiation, we define sensitive periods, review cellular and molecular processes that can explain their restricted temporal window, and discuss challenges in determining the precise timing of the temporal window. We then briefly review programming effects of other hormonal systems and discuss how programming of these systems interact with sexual differentiation.

KW - Estrogen

KW - HPA axis

KW - Leptin

KW - Neuroinflammation

KW - Sexual differentiation

KW - Testosterone

KW - Vasopressin

UR - https://www.scopus.com/pages/publications/84905088790

U2 - 10.1007/7854_2014_286

DO - 10.1007/7854_2014_286

M3 - Article

C2 - 24549723

AN - SCOPUS:84905088790

SN - 1866-3370

VL - 16

SP - 79

EP - 108

JO - Current Topics in Behavioral Neurosciences

JF - Current Topics in Behavioral Neurosciences

ER -

Sensitive periods for hormonal programming of the brain

Abstract

Keywords

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