Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators

Alexandre Bridoux; Huadong Cui; Evgeny Dyskin; Andreea Ruxandra Schmitzer; Murat Yalcin; Shaker A. Mousa

doi:10.1016/j.bmcl.2010.04.011

Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators

Alexandre Bridoux
, Huadong Cui
, Evgeny Dyskin
, Andreea Ruxandra Schmitzer
, Murat Yalcin
, Shaker A. Mousa

Orthopaedics

Albany College of Pharmacy
University of Montreal
Uludag University
King Saud University

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Novel thyroxine analogs with hindered phenol, amino and carboxylic acid groups have been synthesized and the effects of the synthesized compounds on angiogenesis using the chick chorioallantoic membrane and mouse matrigel models have been tested. Pharmacological profiles revealed that thyroxine tolerates numerous modifications on the amino group and remains active. These results provide the rationale for the selection of a novel thyroxine nanoparticle precursor.

Original language	English
Pages (from-to)	3394-3398
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	11
DOIs	https://doi.org/10.1016/j.bmcl.2010.04.011
State	Published - Jun 1 2010

Keywords

Angiogenesis
Esterification
Nanopharmaceutical technology
Silylation
Thyroxine
UV-vis

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10.1016/j.bmcl.2010.04.011

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title = "Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators",

abstract = "Novel thyroxine analogs with hindered phenol, amino and carboxylic acid groups have been synthesized and the effects of the synthesized compounds on angiogenesis using the chick chorioallantoic membrane and mouse matrigel models have been tested. Pharmacological profiles revealed that thyroxine tolerates numerous modifications on the amino group and remains active. These results provide the rationale for the selection of a novel thyroxine nanoparticle precursor.",

keywords = "Angiogenesis, Esterification, Nanopharmaceutical technology, Silylation, Thyroxine, UV-vis",

author = "Alexandre Bridoux and Huadong Cui and Evgeny Dyskin and Schmitzer, \{Andreea Ruxandra\} and Murat Yalcin and Mousa, \{Shaker A.\}",

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doi = "10.1016/j.bmcl.2010.04.011",

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TY - JOUR

T1 - Semisynthesis and pharmacological activities of thyroxine analogs

T2 - Development of new angiogenesis modulators

AU - Bridoux, Alexandre

AU - Cui, Huadong

AU - Dyskin, Evgeny

AU - Schmitzer, Andreea Ruxandra

AU - Yalcin, Murat

AU - Mousa, Shaker A.

PY - 2010/6/1

Y1 - 2010/6/1

N2 - Novel thyroxine analogs with hindered phenol, amino and carboxylic acid groups have been synthesized and the effects of the synthesized compounds on angiogenesis using the chick chorioallantoic membrane and mouse matrigel models have been tested. Pharmacological profiles revealed that thyroxine tolerates numerous modifications on the amino group and remains active. These results provide the rationale for the selection of a novel thyroxine nanoparticle precursor.

AB - Novel thyroxine analogs with hindered phenol, amino and carboxylic acid groups have been synthesized and the effects of the synthesized compounds on angiogenesis using the chick chorioallantoic membrane and mouse matrigel models have been tested. Pharmacological profiles revealed that thyroxine tolerates numerous modifications on the amino group and remains active. These results provide the rationale for the selection of a novel thyroxine nanoparticle precursor.

KW - Angiogenesis

KW - Esterification

KW - Nanopharmaceutical technology

KW - Silylation

KW - Thyroxine

KW - UV-vis

UR - https://www.scopus.com/pages/publications/77953293160

U2 - 10.1016/j.bmcl.2010.04.011

DO - 10.1016/j.bmcl.2010.04.011

M3 - Article

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AN - SCOPUS:77953293160

SN - 0960-894X

VL - 20

SP - 3394

EP - 3398

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 11

ER -

Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators

Abstract

Keywords

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