Semisynthesis and pharmacological activities of Tetrac analogs: Angiogenesis modulators

Alexandre Bridoux; Huadong Cui; Evgeny Dyskin; Murat Yalcin; Shaker A. Mousa

doi:10.1016/j.bmcl.2009.04.094

Semisynthesis and pharmacological activities of Tetrac analogs: Angiogenesis modulators

Alexandre Bridoux
, Huadong Cui
, Evgeny Dyskin
, Murat Yalcin
, Shaker A. Mousa

Orthopaedics

Albany College of Pharmacy
Uludag University

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Novel Tetrac analogs were synthesized and then tested. Anti-angiogenesis efficacy was carried out using the Chick Chorioallantoic Membrane (CAM) model and the mouse matrigel model for angiogenesis. Pharmacological activities showed Tetrac can accommodate numerous modifications and maintain anti-angiogenesis activity.

Original language	English
Pages (from-to)	3259-3263
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	12
DOIs	https://doi.org/10.1016/j.bmcl.2009.04.094
State	Published - Jun 15 2009

Keywords

Angiogenesis
Esterification
HPLC
Nanopharmaceutical technology
Silylation
Tetrac

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10.1016/j.bmcl.2009.04.094

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title = "Semisynthesis and pharmacological activities of Tetrac analogs: Angiogenesis modulators",

abstract = "Novel Tetrac analogs were synthesized and then tested. Anti-angiogenesis efficacy was carried out using the Chick Chorioallantoic Membrane (CAM) model and the mouse matrigel model for angiogenesis. Pharmacological activities showed Tetrac can accommodate numerous modifications and maintain anti-angiogenesis activity.",

keywords = "Angiogenesis, Esterification, HPLC, Nanopharmaceutical technology, Silylation, Tetrac",

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AU - Bridoux, Alexandre

AU - Cui, Huadong

AU - Dyskin, Evgeny

AU - Yalcin, Murat

AU - Mousa, Shaker A.

PY - 2009/6/15

Y1 - 2009/6/15

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AB - Novel Tetrac analogs were synthesized and then tested. Anti-angiogenesis efficacy was carried out using the Chick Chorioallantoic Membrane (CAM) model and the mouse matrigel model for angiogenesis. Pharmacological activities showed Tetrac can accommodate numerous modifications and maintain anti-angiogenesis activity.

KW - Angiogenesis

KW - Esterification

KW - HPLC

KW - Nanopharmaceutical technology

KW - Silylation

KW - Tetrac

UR - https://www.scopus.com/pages/publications/65749099626

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AN - SCOPUS:65749099626

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 12

ER -

Semisynthesis and pharmacological activities of Tetrac analogs: Angiogenesis modulators

Abstract

Keywords

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