Self-assembly of human serum albumin: A simplex phenomenon

Garima Thakur; Kovur Prashanthi; Keren Jiang; Thomas Thundat

doi:10.3390/biom7030069

Self-assembly of human serum albumin: A simplex phenomenon

Garima Thakur
, Kovur Prashanthi
, Keren Jiang
, Thomas Thundat

Department of Chemical and Biological Engineering

University of Alberta

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Spontaneous self-assemblies of biomolecules can generate geometrical patterns. Our findings provide an insight into the mechanism of self-assembled ring pattern generation by human serum albumin (HSA). The self-assembly is a process guided by kinetic and thermodynamic parameters. The generated protein ring patterns display a behavior which is geometrically related to a n-simplex model and is explained through thermodynamics and chemical kinetics.

Original language	English
Article number	69
Journal	Biomolecules
Volume	7
Issue number	3
DOIs	https://doi.org/10.3390/biom7030069
State	Published - Sep 20 2017

Keywords

Geometric pattern
Kinetics
N-simplex
Pascal’s triangle
Protein self-assembly
Thermodynamics

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10.3390/biom7030069

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title = "Self-assembly of human serum albumin: A simplex phenomenon",

abstract = "Spontaneous self-assemblies of biomolecules can generate geometrical patterns. Our findings provide an insight into the mechanism of self-assembled ring pattern generation by human serum albumin (HSA). The self-assembly is a process guided by kinetic and thermodynamic parameters. The generated protein ring patterns display a behavior which is geometrically related to a n-simplex model and is explained through thermodynamics and chemical kinetics.",

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T2 - A simplex phenomenon

AU - Thakur, Garima

AU - Prashanthi, Kovur

AU - Jiang, Keren

AU - Thundat, Thomas

PY - 2017/9/20

Y1 - 2017/9/20

N2 - Spontaneous self-assemblies of biomolecules can generate geometrical patterns. Our findings provide an insight into the mechanism of self-assembled ring pattern generation by human serum albumin (HSA). The self-assembly is a process guided by kinetic and thermodynamic parameters. The generated protein ring patterns display a behavior which is geometrically related to a n-simplex model and is explained through thermodynamics and chemical kinetics.

AB - Spontaneous self-assemblies of biomolecules can generate geometrical patterns. Our findings provide an insight into the mechanism of self-assembled ring pattern generation by human serum albumin (HSA). The self-assembly is a process guided by kinetic and thermodynamic parameters. The generated protein ring patterns display a behavior which is geometrically related to a n-simplex model and is explained through thermodynamics and chemical kinetics.

KW - Geometric pattern

KW - Kinetics

KW - N-simplex

KW - Pascal’s triangle

KW - Protein self-assembly

KW - Thermodynamics

UR - https://www.scopus.com/pages/publications/85031094660

U2 - 10.3390/biom7030069

DO - 10.3390/biom7030069

M3 - Article

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VL - 7

JO - Biomolecules

JF - Biomolecules

IS - 3

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ER -

Self-assembly of human serum albumin: A simplex phenomenon

Abstract

Keywords

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