Segregation of transcription and replication sites into higher order domains

Xiangyun Wei; Jagath Samarabandu; Rakendu S. Devdhar; Alan J. Siegel; Raj Acharya; Ronald Berezney

doi:10.1126/science.281.5382.1502

Segregation of transcription and replication sites into higher order domains

Xiangyun Wei
, Jagath Samarabandu
, Rakendu S. Devdhar
, Alan J. Siegel
, Raj Acharya
, Ronald Berezney

Biological Sciences

SUNY Buffalo
Life Imaging Systems Inc.

Research output: Contribution to journal › Article › peer-review

222 Scopus citations

Abstract

Microscopy shows that individual sites of DNA replication and transcription of mammalian nuclei segregate into sets of roughly 22 and 16 higher order domains, respectively. Each domain set displayed a distinct network-like appearance, including regions of individual domains and interdigitation of domains between the two networks. These data support a dynamic mosaic model for the higher order arrangement of genomic function inside the cell nuclei.

Original language	English
Pages (from-to)	1502-1505
Number of pages	4
Journal	Science
Volume	281
Issue number	5382
DOIs	https://doi.org/10.1126/science.281.5382.1502
State	Published - Sep 4 1998

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10.1126/science.281.5382.1502

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title = "Segregation of transcription and replication sites into higher order domains",

abstract = "Microscopy shows that individual sites of DNA replication and transcription of mammalian nuclei segregate into sets of roughly 22 and 16 higher order domains, respectively. Each domain set displayed a distinct network-like appearance, including regions of individual domains and interdigitation of domains between the two networks. These data support a dynamic mosaic model for the higher order arrangement of genomic function inside the cell nuclei.",

author = "Xiangyun Wei and Jagath Samarabandu and Devdhar, \{Rakendu S.\} and Siegel, \{Alan J.\} and Raj Acharya and Ronald Berezney",

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AU - Wei, Xiangyun

AU - Samarabandu, Jagath

AU - Devdhar, Rakendu S.

AU - Siegel, Alan J.

AU - Acharya, Raj

AU - Berezney, Ronald

PY - 1998/9/4

Y1 - 1998/9/4

N2 - Microscopy shows that individual sites of DNA replication and transcription of mammalian nuclei segregate into sets of roughly 22 and 16 higher order domains, respectively. Each domain set displayed a distinct network-like appearance, including regions of individual domains and interdigitation of domains between the two networks. These data support a dynamic mosaic model for the higher order arrangement of genomic function inside the cell nuclei.

AB - Microscopy shows that individual sites of DNA replication and transcription of mammalian nuclei segregate into sets of roughly 22 and 16 higher order domains, respectively. Each domain set displayed a distinct network-like appearance, including regions of individual domains and interdigitation of domains between the two networks. These data support a dynamic mosaic model for the higher order arrangement of genomic function inside the cell nuclei.

UR - https://www.scopus.com/pages/publications/0032483372

U2 - 10.1126/science.281.5382.1502

DO - 10.1126/science.281.5382.1502

M3 - Article

C2 - 9727975

AN - SCOPUS:0032483372

SN - 0036-8075

VL - 281

SP - 1502

EP - 1505

JO - Science

JF - Science

IS - 5382

ER -

Segregation of transcription and replication sites into higher order domains

Abstract

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