Secretors of HBGA and Susceptibility to Norovirus and Rotavirus Diarrhea

Howard Faden; Beverly A. Schaefer

doi:10.1097/INF.0000000000003218

Secretors of HBGA and Susceptibility to Norovirus and Rotavirus Diarrhea

Pediatrics

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Histo-blood group antigen contains oligosaccharides that serve as receptors for norovirus (NoV) and rotavirus (RV). The receptors are only present on the surface of intestinal mucosal epithelial cells of secretors; therefore, secretors are susceptible to NoV and RV diarrhea and nonsecretors are resistant. The prevalence of secretors in different countries varies between 50% and 90%. Secretor rates evolved in response to environmental pressures such as infectious diseases.

Original language	English
Pages (from-to)	846-851
Number of pages	6
Journal	Pediatric Infectious Disease Journal
Volume	40
Issue number	9
DOIs	https://doi.org/10.1097/INF.0000000000003218
State	Published - Sep 1 2021

Keywords

diarrhea
histo-blood group antigens
norovirus
rotavirus
secretor of HBGA

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10.1097/INF.0000000000003218

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title = "Secretors of HBGA and Susceptibility to Norovirus and Rotavirus Diarrhea",

abstract = "Histo-blood group antigen contains oligosaccharides that serve as receptors for norovirus (NoV) and rotavirus (RV). The receptors are only present on the surface of intestinal mucosal epithelial cells of secretors; therefore, secretors are susceptible to NoV and RV diarrhea and nonsecretors are resistant. The prevalence of secretors in different countries varies between 50\% and 90\%. Secretor rates evolved in response to environmental pressures such as infectious diseases.",

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AU - Schaefer, Beverly A.

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N2 - Histo-blood group antigen contains oligosaccharides that serve as receptors for norovirus (NoV) and rotavirus (RV). The receptors are only present on the surface of intestinal mucosal epithelial cells of secretors; therefore, secretors are susceptible to NoV and RV diarrhea and nonsecretors are resistant. The prevalence of secretors in different countries varies between 50% and 90%. Secretor rates evolved in response to environmental pressures such as infectious diseases.

AB - Histo-blood group antigen contains oligosaccharides that serve as receptors for norovirus (NoV) and rotavirus (RV). The receptors are only present on the surface of intestinal mucosal epithelial cells of secretors; therefore, secretors are susceptible to NoV and RV diarrhea and nonsecretors are resistant. The prevalence of secretors in different countries varies between 50% and 90%. Secretor rates evolved in response to environmental pressures such as infectious diseases.

KW - diarrhea

KW - histo-blood group antigens

KW - norovirus

KW - rotavirus

KW - secretor of HBGA

UR - https://www.scopus.com/pages/publications/85112764107

U2 - 10.1097/INF.0000000000003218

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M3 - Review article

C2 - 34397778

AN - SCOPUS:85112764107

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JF - Pediatric Infectious Disease Journal

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ER -

Secretors of HBGA and Susceptibility to Norovirus and Rotavirus Diarrhea

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Keywords

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