Ropinirole in Bipolar Disorder: Rate of Manic Switching and Change in Disease Severity

Horacio A. Capote; Michelle Rainka; Erica S. Westphal; Jonathan Beecher; Francis M. Gengo

doi:10.1111/ppc.12205

Ropinirole in Bipolar Disorder: Rate of Manic Switching and Change in Disease Severity

Horacio A. Capote
, Michelle Rainka
, Erica S. Westphal
, Jonathan Beecher
, Francis M. Gengo

Pharmacy

Dent. Neurologic Institute

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

PURPOSE: To determine the effects of ropinirole on manic switching and disease severity in bipolar disorder. DESIGN AND METHODS: A cross-sectional survey was conducted in 23 bipolar depressed patients using ropinirole combination therapy (Young Mania Rating Scale [YMRS], Bipolar Inventory of Symptoms Scale [BISS]). Retrospective Clinical Global Impression of Change (CGI-C) and CGI-S (Severity) were captured via chart review. FINDINGS: One patient (4.3%) experienced induction of mania (YMRS). All patients responded or partially responded to ropinirole (CGIs). YMRS and BISS mania scores were correlated. PRACTICE IMPLICATIONS: Ropinirole has a low rate of manic switching and significantly reduces bipolar depression severity.

Original language	English
Pages (from-to)	100-106
Number of pages	7
Journal	Perspectives in Psychiatric Care
Volume	54
Issue number	2
DOIs	https://doi.org/10.1111/ppc.12205
State	Published - Apr 2018

Keywords

bipolar
BISS
dopamine agonists
mania
ropinirole
YMRS

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10.1111/ppc.12205

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title = "Ropinirole in Bipolar Disorder: Rate of Manic Switching and Change in Disease Severity",

abstract = "PURPOSE: To determine the effects of ropinirole on manic switching and disease severity in bipolar disorder. DESIGN AND METHODS: A cross-sectional survey was conducted in 23 bipolar depressed patients using ropinirole combination therapy (Young Mania Rating Scale [YMRS], Bipolar Inventory of Symptoms Scale [BISS]). Retrospective Clinical Global Impression of Change (CGI-C) and CGI-S (Severity) were captured via chart review. FINDINGS: One patient (4.3\%) experienced induction of mania (YMRS). All patients responded or partially responded to ropinirole (CGIs). YMRS and BISS mania scores were correlated. PRACTICE IMPLICATIONS: Ropinirole has a low rate of manic switching and significantly reduces bipolar depression severity.",

keywords = "bipolar, BISS, dopamine agonists, mania, ropinirole, YMRS",

author = "Capote, \{Horacio A.\} and Michelle Rainka and Westphal, \{Erica S.\} and Jonathan Beecher and Gengo, \{Francis M.\}",

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year = "2018",

month = apr,

doi = "10.1111/ppc.12205",

language = "English",

volume = "54",

pages = "100--106",

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T1 - Ropinirole in Bipolar Disorder

T2 - Rate of Manic Switching and Change in Disease Severity

AU - Capote, Horacio A.

AU - Rainka, Michelle

AU - Westphal, Erica S.

AU - Beecher, Jonathan

AU - Gengo, Francis M.

PY - 2018/4

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N2 - PURPOSE: To determine the effects of ropinirole on manic switching and disease severity in bipolar disorder. DESIGN AND METHODS: A cross-sectional survey was conducted in 23 bipolar depressed patients using ropinirole combination therapy (Young Mania Rating Scale [YMRS], Bipolar Inventory of Symptoms Scale [BISS]). Retrospective Clinical Global Impression of Change (CGI-C) and CGI-S (Severity) were captured via chart review. FINDINGS: One patient (4.3%) experienced induction of mania (YMRS). All patients responded or partially responded to ropinirole (CGIs). YMRS and BISS mania scores were correlated. PRACTICE IMPLICATIONS: Ropinirole has a low rate of manic switching and significantly reduces bipolar depression severity.

AB - PURPOSE: To determine the effects of ropinirole on manic switching and disease severity in bipolar disorder. DESIGN AND METHODS: A cross-sectional survey was conducted in 23 bipolar depressed patients using ropinirole combination therapy (Young Mania Rating Scale [YMRS], Bipolar Inventory of Symptoms Scale [BISS]). Retrospective Clinical Global Impression of Change (CGI-C) and CGI-S (Severity) were captured via chart review. FINDINGS: One patient (4.3%) experienced induction of mania (YMRS). All patients responded or partially responded to ropinirole (CGIs). YMRS and BISS mania scores were correlated. PRACTICE IMPLICATIONS: Ropinirole has a low rate of manic switching and significantly reduces bipolar depression severity.

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KW - ropinirole

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Ropinirole in Bipolar Disorder: Rate of Manic Switching and Change in Disease Severity

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Keywords

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